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Losartan and amlodipine and hydrochlorothiazide
This triple-combination antihypertensive reduces blood pressure through three complementary mechanisms: angiotensin II receptor blockade, calcium channel inhibition, and thiazide diuresis.
This triple-combination antihypertensive reduces blood pressure by blocking angiotensin II receptors, relaxing vascular smooth muscle, and reducing sodium and fluid retention. Used for Hypertension (high blood pressure).
At a glance
| Generic name | Losartan and amlodipine and hydrochlorothiazide |
|---|---|
| Sponsor | Hotel Dieu de France Hospital |
| Drug class | Antihypertensive combination (ARB + calcium channel blocker + thiazide diuretic) |
| Target | Angiotensin II type 1 receptor (AT1R), L-type calcium channels, sodium-chloride cotransporter |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Losartan blocks angiotensin II receptors to reduce vasoconstriction and aldosterone secretion. Amlodipine inhibits L-type calcium channels in vascular smooth muscle to promote vasodilation. Hydrochlorothiazide acts as a thiazide diuretic to reduce blood volume and sodium reabsorption. Together, these agents provide synergistic antihypertensive effects.
Approved indications
- Hypertension (essential hypertension in patients requiring triple-agent therapy)
Common side effects
- Dizziness
- Fatigue
- Headache
- Hyperuricemia
- Hypokalemia
- Peripheral edema
- Cough
Key clinical trials
- Efficacy and Safety of a Single-pill Fixed Combination of Sufficient Losartan/Hydrochlorothiazide in Chinese Hypertensive Patients (PHASE4)
- Hydrochlorothiazide (+) Losartan Potassium vs. Amlodipine Comparative Study (0954A-314) (PHASE4)
- Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED) (PHASE4)
- Integrating Hypertension Management in DSD for HIV
- N-of-1 Trials In Children With Hypertension (PHASE4)
- The SCCS Polypill Pilot Trial (PHASE2)
- ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
- Phase 4 Study of the Efficacy of Losartan Based Therapy in Hypertensives With and Without Diabetes (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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