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Loprox Cream 0.77%
Ciclopirox olamine disrupts fungal cell membrane and mitochondrial function by chelating polyvalent cations, leading to fungal cell death.
Ciclopirox olamine disrupts fungal cell membrane and mitochondrial function by chelating polyvalent cations, leading to fungal cell death. Used for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).
At a glance
| Generic name | Loprox Cream 0.77% |
|---|---|
| Also known as | Loprox Cream |
| Sponsor | Padagis LLC |
| Drug class | Antifungal agent |
| Target | Fungal cell membrane and mitochondrial enzymes (polyvalent cation-dependent) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Ciclopirox is a broad-spectrum antifungal agent that works by inhibiting the transport of essential ions and disrupting multiple fungal metabolic pathways. It chelates iron and other polyvalent cations required for fungal enzyme function, affecting both the cell membrane and mitochondrial respiration. This multi-target mechanism makes it effective against a wide range of dermatophytes, yeasts, and non-dermatophyte molds.
Approved indications
- Tinea pedis (athlete's foot)
- Tinea corporis (ringworm)
- Tinea cruris (jock itch)
- Candidiasis (cutaneous yeast infections)
- Pityriasis versicolor
Common side effects
- Pruritus at application site
- Erythema
- Burning sensation
- Contact dermatitis
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |