{"id":"loprox-cream-0-77","safety":{"commonSideEffects":[{"rate":null,"effect":"Pruritus at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Burning sensation"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ciclopirox is a broad-spectrum antifungal agent that works by inhibiting the transport of essential ions and disrupting multiple fungal metabolic pathways. It chelates iron and other polyvalent cations required for fungal enzyme function, affecting both the cell membrane and mitochondrial respiration. This multi-target mechanism makes it effective against a wide range of dermatophytes, yeasts, and non-dermatophyte molds.","oneSentence":"Ciclopirox olamine disrupts fungal cell membrane and mitochondrial function by chelating polyvalent cations, leading to fungal cell death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:19:25.124Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea cruris (jock itch)"},{"name":"Candidiasis (cutaneous yeast infections)"},{"name":"Pityriasis versicolor"}]},"trialDetails":[{"nctId":"NCT00802672","phase":"PHASE3","title":"Safety and Equivalence of a Generic Ciclopirox Olamine Cream Compared to the Reference Ciclopirox Cream 0.77% for the Treatment of Tinea Pedis","status":"COMPLETED","sponsor":"Padagis LLC","startDate":"2003-12","conditions":"Tinea Pedis","enrollment":561}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Loprox Cream"],"phase":"phase_3","status":"active","brandName":"Loprox Cream 0.77%","genericName":"Loprox Cream 0.77%","companyName":"Padagis LLC","companyId":"padagis-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciclopirox olamine disrupts fungal cell membrane and mitochondrial function by chelating polyvalent cations, leading to fungal cell death. Used for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}