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local infiltration of liposomal bupivacaine
local infiltration of liposomal bupivacaine is a Local anesthetic (amide class) Small molecule drug developed by TriHealth Inc.. It is currently FDA-approved for Local infiltration anesthesia for surgical procedures, Postoperative pain management via local infiltration.
Liposomal bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, with extended duration due to liposomal encapsulation.
Liposomal bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, with extended duration due to liposomal encapsulation. Used for Local infiltration anesthesia for surgical procedures, Postoperative pain management via local infiltration.
At a glance
| Generic name | local infiltration of liposomal bupivacaine |
|---|---|
| Sponsor | TriHealth Inc. |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is an amide-class local anesthetic that inhibits sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and action potential propagation. The liposomal formulation provides sustained release of the active drug, extending the duration of anesthesia at the infiltration site compared to conventional bupivacaine solutions.
Approved indications
- Local infiltration anesthesia for surgical procedures
- Postoperative pain management via local infiltration
Common side effects
- Injection site reactions
- Systemic toxicity (rare, dose-dependent)
- Transient paresthesia
Key clinical trials
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population (PHASE2)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery (NA)
- Liposomal Bupivacaine Versus Ropivacaine for Preperitoneal Infiltration Analgesia in Upper Abdominal Laparotomy (NA)
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty (PHASE4)
- TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant (PHASE4)
- A Study of Liposomal Bupivacaine Versus 0.25% Bupivacaine Hydrochloride Post Breast Reduction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- local infiltration of liposomal bupivacaine CI brief — competitive landscape report
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- TriHealth Inc. portfolio CI
Frequently asked questions about local infiltration of liposomal bupivacaine
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Related
- Drug class: All Local anesthetic (amide class) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: TriHealth Inc. — full pipeline
- Therapeutic area: All drugs in Anesthesia / Pain Management
- Indication: Drugs for Local infiltration anesthesia for surgical procedures
- Indication: Drugs for Postoperative pain management via local infiltration
- Compare: local infiltration of liposomal bupivacaine vs similar drugs
- Pricing: local infiltration of liposomal bupivacaine cost, discount & access