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local infiltration
Local infiltration is a surgical/anesthetic technique that delivers anesthetic agents directly into tissue at the site of procedure to block pain sensation in that specific area.
Local infiltration is a surgical/anesthetic technique that delivers anesthetic agents directly into tissue at the site of procedure to block pain sensation in that specific area. Used for Local anesthesia for minor surgical procedures, Dental anesthesia, Wound infiltration and pain management.
At a glance
| Generic name | local infiltration |
|---|---|
| Also known as | saline |
| Sponsor | The Catholic University of Korea |
| Drug class | Local anesthetic |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Local infiltration involves injecting local anesthetic drugs (such as lidocaine or bupivacaine) directly into the surgical or procedural site, where they diffuse through tissue and block sodium channels in nerve fibers, preventing pain signal transmission. This technique provides localized anesthesia without systemic effects and is commonly used for minor surgical procedures, dental work, and wound management.
Approved indications
- Local anesthesia for minor surgical procedures
- Dental anesthesia
- Wound infiltration and pain management
Common side effects
- Injection site pain or discomfort
- Allergic reaction (rare with amide anesthetics)
- Systemic toxicity if overdosed
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- Treatment of Crohn's Complex Perianal Fistulas With Tissue Transplantation by Local Injection of Micro-fragmented Autologous Adipose Tissue. (NA)
- Comparison of Two Minimally Invasive Approaches for Masking Molar-Incisor Hypomineralization Opacities (NA)
- A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China. (PHASE3)
- Assessment of Maxillary Local Anesthesia Infiltration Using Needle-free Jet vs Conventional Syringe in Tooth Extraction (NA)
- "Comparison of the Effects of Resin Infiltrant, Fluoride Varnish, and the Combined Application of Resin Infiltrant and Fluoride Varnish on Primary Molars in the Treatment of Proximal Non-Cavitated Carious Lesions in Children." (NA)
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- local infiltration CI brief — competitive landscape report
- local infiltration updates RSS · CI watch RSS
- The Catholic University of Korea portfolio CI