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Local corticosteroid injection
Local corticosteroid injection delivers glucocorticoids directly to inflamed tissues to suppress local immune and inflammatory responses.
Local corticosteroid injection delivers glucocorticoids directly to inflamed tissues to suppress local immune and inflammatory responses. Used for Intra-articular inflammation in osteoarthritis and rheumatoid arthritis, Soft tissue inflammation and bursitis, Tendinitis and tenosynovitis.
At a glance
| Generic name | Local corticosteroid injection |
|---|---|
| Also known as | Methyl prednisolone acetate 80mg |
| Sponsor | Dojode, Chetan M., MBBS, MS |
| Drug class | Corticosteroid |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Rheumatology, Orthopedics, Dermatology, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Corticosteroids bind to glucocorticoid receptors in target tissues, suppressing pro-inflammatory cytokine production, reducing immune cell infiltration, and decreasing local edema and inflammation. By injecting directly into the affected area, high local concentrations are achieved while minimizing systemic exposure and adverse effects.
Approved indications
- Intra-articular inflammation (e.g., osteoarthritis, rheumatoid arthritis)
- Soft tissue inflammation (e.g., bursitis, tendinitis)
- Intralesional dermatologic conditions
Common side effects
- Local pain or discomfort at injection site
- Transient local swelling
- Infection at injection site
- Steroid flare (transient increase in pain)
- Skin atrophy (with repeated intradermal injections)
Key clinical trials
- Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone (PHASE4)
- Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipients (PHASE2)
- Hyaluronic Acid Injection in Idiopathic Carpal Tunnel Syndrome; is it Effective as Local Corticosteroids (PHASE3)
- A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) (PHASE2)
- Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata (PHASE4)
- Erector Spinae Plane vs Caudal Epidural Steroid in Lumbar Spinal Stenosis Resistant to Conservative Therapy (NA)
- Ultrasound-Guided Intra-Articular vs Gluteal Intramuscular Corticosteroid Injection for Frozen Shoulder (PHASE4)
- Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Local corticosteroid injection CI brief — competitive landscape report
- Local corticosteroid injection updates RSS · CI watch RSS
- Dojode, Chetan M., MBBS, MS portfolio CI