{"id":"local-corticosteroid-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Local pain or discomfort at injection site"},{"rate":null,"effect":"Transient local swelling"},{"rate":null,"effect":"Infection at injection site"},{"rate":null,"effect":"Steroid flare (transient increase in pain)"},{"rate":null,"effect":"Skin atrophy (with repeated intradermal injections)"}]},"_chembl":{"chemblId":"CHEMBL2108760","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Corticosteroids bind to glucocorticoid receptors in target tissues, suppressing pro-inflammatory cytokine production, reducing immune cell infiltration, and decreasing local edema and inflammation. By injecting directly into the affected area, high local concentrations are achieved while minimizing systemic exposure and adverse effects.","oneSentence":"Local corticosteroid injection delivers glucocorticoids directly to inflamed tissues to suppress local immune and inflammatory responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:40.593Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intra-articular inflammation (e.g., osteoarthritis, rheumatoid arthritis)"},{"name":"Soft tissue inflammation (e.g., bursitis, tendinitis)"},{"name":"Intralesional dermatologic conditions"}]},"trialDetails":[{"nctId":"NCT05845125","phase":"PHASE4","title":"Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone","status":"TERMINATED","sponsor":"Claire Bourgeois","startDate":"2023-05-21","conditions":"Shoulder 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Migraine, Chronic Migraine, Headache","enrollment":64},{"nctId":"NCT03724903","phase":"NA","title":"Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis","status":"COMPLETED","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","startDate":"2019-04-01","conditions":"Granulomatous Mastitis","enrollment":140},{"nctId":"NCT04744675","phase":"PHASE2","title":"Peripheral Nerve Injections for CRPS","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ottawa Hospital Research Institute","startDate":"2024-05-30","conditions":"Complex Regional Pain Syndromes","enrollment":50},{"nctId":"NCT04232358","phase":"NA","title":"Resistance Training and Injection Treatment for Achilles Enthesopathy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bispebjerg Hospital","startDate":"2021-05-04","conditions":"Achilles Entesopathy","enrollment":50},{"nctId":"NCT03614793","phase":"NA","title":"A Prospective Trial of Cooled Radiofrequency Ablation of Medial Branch Nerves Versus Facet Joint Injection of Corticosteroid for the Treatment of Lumbar Facet Syndrome","status":"COMPLETED","sponsor":"University of Utah","startDate":"2018-10-01","conditions":"Lumbar Facet Syndrome","enrollment":39},{"nctId":"NCT02735707","phase":"PHASE3","title":"Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2016-04-11","conditions":"Community-acquired Pneumonia, Influenza, COVID-19","enrollment":20000},{"nctId":"NCT06457828","phase":"NA","title":"Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial","status":"RECRUITING","sponsor":"Suez Canal University","startDate":"2021-02-01","conditions":"Postoperative Pain, Symptomatic Irreversible Pulpitis","enrollment":40},{"nctId":"NCT06382623","phase":"","title":"Efficacies of Different Managements in Patients With Trigger Finger","status":"COMPLETED","sponsor":"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital","startDate":"2022-10-01","conditions":"Trigger Finger","enrollment":30},{"nctId":"NCT06272682","phase":"NA","title":"Corticosteroids in Carpal Tunnel Syndrome. 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