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Listerine Total Care Zero
Listerine Total Care Zero is an antimicrobial oral rinse that kills bacteria and reduces plaque and gingivitis without alcohol.
Listerine Total Care Zero is an antimicrobial oral rinse that kills bacteria and reduces plaque and gingivitis without alcohol. Used for Reduction of plaque and gingivitis, Antimicrobial oral hygiene maintenance.
At a glance
| Generic name | Listerine Total Care Zero |
|---|---|
| Sponsor | Johnson & Johnson Consumer Inc. (J&JCI) |
| Drug class | Antimicrobial oral rinse |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
The product contains essential oils (eucalyptol, menthol, methyl salicylate, thymol) and other antimicrobial agents that disrupt bacterial cell membranes and inhibit microbial growth in the oral cavity. The alcohol-free formulation maintains antimicrobial efficacy while reducing irritation and drying effects associated with traditional alcohol-based mouthwashes.
Approved indications
- Reduction of plaque and gingivitis
- Antimicrobial oral hygiene maintenance
Common side effects
- Oral irritation
- Taste alteration
- Staining (minimal with alcohol-free formulation)
Key clinical trials
- Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash (EARLY_PHASE1)
- Clinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis (PHASE4)
- Determination of the Oral Irritation Potential of a Fluoride Rinse in Children (NA)
- A Two-Week Study of an Anticavity Low pH Mouthwash (PHASE4)
- A Study to Investigate Salivary Flow and Potential of Hydrogen (pH) Following Use of Essential-Oil Containing Mouthwashes (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Listerine Total Care Zero CI brief — competitive landscape report
- Listerine Total Care Zero updates RSS · CI watch RSS
- Johnson & Johnson Consumer Inc. (J&JCI) portfolio CI