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Listerine Total Care Mouthwash
Listerine Total Care Mouthwash is a Antimicrobial mouthwash Small molecule drug developed by King Abdullah University Hospital. It is currently FDA-approved for Reduction of plaque and gingivitis, Prevention of bad breath, General oral hygiene and antimicrobial protection.
Listerine Total Care Mouthwash kills oral bacteria and reduces plaque formation through a combination of essential oils and antimicrobial agents.
Listerine Total Care Mouthwash kills oral bacteria and reduces plaque formation through a combination of essential oils and antimicrobial agents. Used for Plaque and gingivitis reduction, Bad breath prevention, Cavity prevention (fluoride-containing formulations).
At a glance
| Generic name | Listerine Total Care Mouthwash |
|---|---|
| Sponsor | King Abdullah University Hospital |
| Drug class | Antimicrobial mouthwash |
| Modality | Small molecule |
| Therapeutic area | Oral Health / Dentistry |
| Phase | FDA-approved |
Mechanism of action
The mouthwash contains a blend of essential oils (eucalyptol, menthol, methyl salicylate, thymol) that penetrate bacterial cell membranes and disrupt their metabolic processes, leading to cell death. This antimicrobial action reduces the bacterial load in the oral cavity, thereby decreasing plaque accumulation, gingivitis, and bad breath. The formulation also provides anti-inflammatory benefits to support overall oral health.
Approved indications
- Reduction of plaque and gingivitis
- Prevention of bad breath
- General oral hygiene and antimicrobial protection
Common side effects
- Tooth staining
- Oral irritation or burning sensation
- Allergic reaction (rare)
Key clinical trials
- Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash (EARLY_PHASE1)
- Effect of Different Products to Support Plaque Control During Daytime (NA)
- The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes (NA)
- Imaging-based Assessment of Oral Biofilm and Gingival Health (NA)
- Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children (NA)
- Clinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis (PHASE4)
- Determination of the Oral Irritation Potential of a Fluoride Rinse in Children (NA)
- Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Listerine Total Care Mouthwash CI brief — competitive landscape report
- Listerine Total Care Mouthwash updates RSS · CI watch RSS
- King Abdullah University Hospital portfolio CI
Frequently asked questions about Listerine Total Care Mouthwash
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Related
- Drug class: All Antimicrobial mouthwash drugs
- Manufacturer: King Abdullah University Hospital — full pipeline
- Therapeutic area: All drugs in Oral Health / Dentistry
- Indication: Drugs for Reduction of plaque and gingivitis
- Indication: Drugs for Prevention of bad breath
- Indication: Drugs for General oral hygiene and antimicrobial protection
- Compare: Listerine Total Care Mouthwash vs similar drugs
- Pricing: Listerine Total Care Mouthwash cost, discount & access