{"id":"listerine-total-care-mouthwash","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth staining"},{"rate":null,"effect":"Oral irritation or burning sensation"},{"rate":null,"effect":"Allergic reaction (rare)"}]},"_chembl":null,"_dailymed":{"setId":"4b0404af-309f-7c31-e063-6294a90a5aa1","title":"LISTERINE TOTAL CARE INTENSE ANTICAVITY FLUORIDE MOUTHWASH (SODIUM FLUORIDE) MOUTHWASH [KENVUE BRANDS LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The mouthwash contains a blend of essential oils (eucalyptol, menthol, methyl salicylate, thymol) that penetrate bacterial cell membranes and disrupt their metabolic processes, leading to cell death. This antimicrobial action reduces the bacterial load in the oral cavity, thereby decreasing plaque accumulation, gingivitis, and bad breath. The formulation also provides anti-inflammatory benefits to support overall oral health.","oneSentence":"Listerine Total Care Mouthwash kills oral bacteria and reduces plaque formation through a combination of essential oils and antimicrobial agents.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T06:12:12.196Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of plaque and gingivitis"},{"name":"Prevention of bad breath"},{"name":"General oral hygiene and antimicrobial protection"}]},"trialDetails":[{"nctId":"NCT03384537","phase":"EARLY_PHASE1","title":"Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash","status":"RECRUITING","sponsor":"Cairo University","startDate":"2024-02-08","conditions":"Dental Diseases","enrollment":30},{"nctId":"NCT07382310","phase":"NA","title":"Effect of Different Products to Support Plaque Control During Daytime","status":"COMPLETED","sponsor":"King Abdullah University Hospital","startDate":"2020-09-18","conditions":"Dental Plaque, Dental Plaque Accumulation, Mouthwashes","enrollment":20},{"nctId":"NCT07364565","phase":"NA","title":"The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes","status":"RECRUITING","sponsor":"King Abdullah University Hospital","startDate":"2025-12-01","conditions":"Dental Plaque, Patient Reported Outcome, Gingival Inflammation and Bleeding","enrollment":44},{"nctId":"NCT05470023","phase":"NA","title":"Imaging-based Assessment of Oral Biofilm and Gingival Health","status":"RECRUITING","sponsor":"University of California, Irvine","startDate":"2022-09-01","conditions":"Plaque, Dental, Gingivitis","enrollment":275},{"nctId":"NCT07241052","phase":"NA","title":"Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children","status":"NOT_YET_RECRUITING","sponsor":"Anabio R&D","startDate":"2025-12-01","conditions":"Dental Caries","enrollment":130},{"nctId":"NCT06904742","phase":"PHASE4","title":"Clinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis","status":"COMPLETED","sponsor":"Altinbas University","startDate":"2024-02-12","conditions":"Periodontal Diseases","enrollment":52},{"nctId":"NCT06798441","phase":"NA","title":"Determination of the Oral Irritation Potential of a Fluoride Rinse in Children","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2025-01-20","conditions":"Healthy","enrollment":161},{"nctId":"NCT01236963","phase":"NA","title":"Essential Oils Mouth Rinse and Dental Floss: Efficacy on Interproximal Gingivitis and Dental Plaque Accumulation","status":"COMPLETED","sponsor":"University of Lisbon","startDate":"2007-09","conditions":"Gingivitis, Dental Plaque Accumulation","enrollment":60},{"nctId":"NCT06010758","phase":"PHASE4","title":"A Two-Week Study of an Anticavity Low pH Mouthwash","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2023-07-17","conditions":"Healthy","enrollment":163},{"nctId":"NCT06136455","phase":"PHASE4","title":"A Study to Investigate Salivary Flow and Potential of Hydrogen (pH) Following Use of Essential-Oil Containing Mouthwashes","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. (J&JCI)","startDate":"2023-11-13","conditions":"Healthy","enrollment":164},{"nctId":"NCT05178823","phase":"PHASE4","title":"Short- and Long Term Antibacterial Effects of a Single Rinse With Different Mouthwashes: a Randomized Clinical Trial","status":"COMPLETED","sponsor":"Semmelweis University","startDate":"2017-06-01","conditions":"Gingival Diseases, Caries","enrollment":171},{"nctId":"NCT03886623","phase":"NA","title":"A Systematic Oral Care Program in Post-Mechanically Ventilated, Post-Intensive Care Patients","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2011-06","conditions":"Methicillin-resistant Staphylococcus Aureus, Methicillin-Sensitive Staphylococcus Aureus Infection","enrollment":80},{"nctId":"NCT01706874","phase":"","title":"Effect Assessment of Periodontal Prophylaxis on Rheumatoid Arthritis Activity.","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2012-11-20","conditions":"Anti-CCP Positive Early Rheumatoid Arthritis","enrollment":92},{"nctId":"NCT02123563","phase":"PHASE4","title":"Mechanical-chemical Gingival Therapy in Diabetics and/or Obese","status":"COMPLETED","sponsor":"University of Taubate","startDate":"2012-06","conditions":"Gingivitis, Diabetes, Obesity","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Listerine Total Care Mouthwash","genericName":"Listerine Total Care Mouthwash","companyName":"King Abdullah University Hospital","companyId":"king-abdullah-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Listerine Total Care Mouthwash kills oral bacteria and reduces plaque formation through a combination of essential oils and antimicrobial agents. Used for Plaque and gingivitis reduction, Bad breath prevention, Cavity prevention (fluoride-containing formulations).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}