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lidocaine+systemic tramadol
Lidocaine is a local anesthetic that blocks nerve signals, while tramadol is a weak opioid agonist and norepinephrine reuptake inhibitor that relieves pain.
Lidocaine is a local anesthetic that blocks nerve signals, while tramadol is a weak opioid agonist and norepinephrine reuptake inhibitor that relieves pain. Used for Moderate to severe pain, Postoperative pain.
At a glance
| Generic name | lidocaine+systemic tramadol |
|---|---|
| Also known as | tramadol |
| Sponsor | Bagcilar Training and Research Hospital |
| Drug class | Local anesthetic and weak opioid agonist |
| Target | Mu-opioid receptor, Norepinephrine transporter |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
Lidocaine works by stabilizing the neuronal membrane and blocking the generation and conduction of nerve impulses. Tramadol, on the other hand, binds to mu-opioid receptors and inhibits the reuptake of norepinephrine, resulting in analgesia.
Approved indications
- Moderate to severe pain
- Postoperative pain
Common side effects
- Dizziness
- Nausea
- Vomiting
- Headache
- Fatigue
Key clinical trials
- TAP Block With Lidocaine and Ropivacaine 0.2% (0.4 ml/kg/Side) for Pain and Opioid Reduction After Hysterectomy (NA)
- Comparative Efficacy of ESPB and EOPB for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomized Controlled Trial (External Oblique Intercostal Plan Block (EOPB) and Erector Spina Plan Block (ESPB) ) (NA)
- Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |