{"id":"lidocaine-systemic-tramadol","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Lidocaine works by stabilizing the neuronal membrane and blocking the generation and conduction of nerve impulses. Tramadol, on the other hand, binds to mu-opioid receptors and inhibits the reuptake of norepinephrine, resulting in analgesia.","oneSentence":"Lidocaine is a local anesthetic that blocks nerve signals, while tramadol is a weak opioid agonist and norepinephrine reuptake inhibitor that relieves pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:19:05.423Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain"},{"name":"Postoperative pain"}]},"trialDetails":[{"nctId":"NCT07139691","phase":"NA","title":"TAP Block With Lidocaine and Ropivacaine 0.2% (0.4 ml/kg/Side) for Pain and Opioid Reduction After Hysterectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Matild Keresztes","startDate":"2024-01-12","conditions":"Postoperative Pain Following Hysterectomy","enrollment":82},{"nctId":"NCT07057934","phase":"NA","title":"Comparative Efficacy of ESPB and EOPB for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomized Controlled Trial (External Oblique Intercostal Plan Block (EOPB) and Erector Spina Plan Block (ESPB) )","status":"COMPLETED","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2024-04-01","conditions":"Postoperative Pain, Cholelithiasis, Acute Pain","enrollment":90},{"nctId":"NCT02658721","phase":"PHASE3","title":"Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery","status":"COMPLETED","sponsor":"Bagcilar Training and Research Hospital","startDate":"2013-01","conditions":"Anesthesia","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["tramadol"],"phase":"phase_3","status":"active","brandName":"lidocaine+systemic tramadol","genericName":"lidocaine+systemic tramadol","companyName":"Bagcilar Training and Research Hospital","companyId":"bagcilar-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine is a local anesthetic that blocks nerve signals, while tramadol is a weak opioid agonist and norepinephrine reuptake inhibitor that relieves pain. Used for Moderate to severe pain, Postoperative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}