Last reviewed · How we verify
Lidocaine-Prilocaine Cream 2.5-2.5%
Lidocaine and prilocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Lidocaine and prilocaine are local anesthetics that block sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia of intact skin prior to minor procedures (venipuncture, IV insertion, laser treatment), Topical anesthesia of genital mucous membranes.
At a glance
| Generic name | Lidocaine-Prilocaine Cream 2.5-2.5% |
|---|---|
| Sponsor | Centre Hospitalier le Mans |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Both lidocaine and prilocaine work by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, which prevents depolarization and action potential generation. This combination cream is applied topically to provide rapid local anesthesia and analgesia. The eutectic mixture (EMLA) formulation allows both agents to penetrate the skin effectively as an oil-in-water emulsion.
Approved indications
- Topical anesthesia for minor surgical procedures and skin procedures
- Anesthesia prior to venipuncture or intravenous cannulation
- Relief of pain associated with minor skin conditions
Common side effects
- Skin blanching or erythema
- Temporary skin irritation or rash
- Methemoglobinemia (rare, especially in infants)
- Allergic contact dermatitis
Key clinical trials
- Efficacy and Safety of Combined Nanofat Injection With Either Platelet Rich Fibrin or Microneedling Versus Nanofat Injection Alone in the Treatment of Facial Atrophic Post Acne Scars (NA)
- Virtual Reality Goggle Utilization for Venipuncture Distraction (NA)
- Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face (PHASE2, PHASE3)
- Efficacy Of Combined Microneedling Plus Tretinoin In Treatment Of Stria Rubra (PHASE1)
- Use of Cervical Cap and Menstrual Disc for Application of Topical Anesthetic Prior to IUD Insertion (NA)
- Local Anesthesia Before Bulkamid Injection (NA)
- Pharmacological and Nonpharmacological Methods for Children in Venipuncture Pain (NA)
- The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine-Prilocaine Cream 2.5-2.5% CI brief — competitive landscape report
- Lidocaine-Prilocaine Cream 2.5-2.5% updates RSS · CI watch RSS
- Centre Hospitalier le Mans portfolio CI