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Lidocaine lubricant
Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia and lubrication for medical procedures, Catheterization and urological procedures, Endoscopic procedures.
At a glance
| Generic name | Lidocaine lubricant |
|---|---|
| Also known as | xylocaine jelly (2%) AstraZeneca |
| Sponsor | Simon Fraser University |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine reversibly binds to voltage-gated sodium channels on the inner surface of nerve cell membranes, inhibiting sodium influx and preventing depolarization. This suppresses the generation and propagation of action potentials in sensory nerves, producing local anesthesia. When formulated as a lubricant, it provides topical anesthetic effect to reduce discomfort during medical procedures or catheterization.
Approved indications
- Topical anesthesia and lubrication for medical procedures
- Catheterization and urological procedures
- Endoscopic procedures
Common side effects
- Local irritation or burning
- Allergic contact dermatitis
- Systemic toxicity (if absorbed in large quantities)
Key clinical trials
- 2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy (NA)
- Lidocaine for Pessary Check Pain Reduction (PHASE3)
- Lessons on Urethral Lidocaine in Urodynamics (PHASE4)
- Bowel Care and Cardiovascular Function After Spinal Cord Injury (PHASE4)
- Evaluation of Efficacy of Platelet Rich Plasma as Anew Modality for Treatment of Atrophic Rhinitis (NA)
- The Use of Topical Anaesthetic in the Banding of Internal Haemorrhoids (PHASE2)
- Cystoscopy in Females: Is There a Difference Between Rigid and Flex Cystoscopy, and Does it Require Local Anasthesia? (NA)
- Contribution of Urethral Sensory Feedback in Voiding Efficiency (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine lubricant CI brief — competitive landscape report
- Lidocaine lubricant updates RSS · CI watch RSS
- Simon Fraser University portfolio CI