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When formulated as a lubricant, it provides topical anesthetic effect to reduce discomfort during medical procedures or catheterization.","oneSentence":"Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:22.089Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia and lubrication for medical procedures"},{"name":"Catheterization and urological procedures"},{"name":"Endoscopic procedures"}]},"trialDetails":[{"nctId":"NCT06420388","phase":"NA","title":"2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy","status":"RECRUITING","sponsor":"E-DA Hospital","startDate":"2023-05-01","conditions":"Surgery, Pain, Postoperative","enrollment":400},{"nctId":"NCT05493735","phase":"PHASE3","title":"Lidocaine for Pessary Check Pain Reduction","status":"COMPLETED","sponsor":"University of South Florida","startDate":"2022-09-08","conditions":"Pelvic Organ Prolapse, Stress Urinary Incontinence","enrollment":66},{"nctId":"NCT04038099","phase":"PHASE4","title":"Lessons on Urethral Lidocaine in Urodynamics","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2019-08-14","conditions":"Urethra Issue, Pelvic Organ Prolapse, Urinary Incontinence","enrollment":63},{"nctId":"NCT01567605","phase":"PHASE4","title":"Bowel Care and Cardiovascular Function After Spinal Cord Injury","status":"COMPLETED","sponsor":"Simon Fraser University","startDate":"2012-03","conditions":"Spinal Cord Injury","enrollment":13},{"nctId":"NCT04717960","phase":"NA","title":"Evaluation of Efficacy of Platelet Rich Plasma as Anew Modality for Treatment of Atrophic Rhinitis","status":"UNKNOWN","sponsor":"Sohag University","startDate":"2021-02-01","conditions":"Atrophic Rhinitis","enrollment":40},{"nctId":"NCT04031131","phase":"PHASE2","title":"The Use of Topical Anaesthetic in the Banding of Internal Haemorrhoids","status":"COMPLETED","sponsor":"Julie Dawson","startDate":"2019-10-17","conditions":"Hemorrhoids","enrollment":38},{"nctId":"NCT03210038","phase":"NA","title":"Cystoscopy in Females: Is There a Difference Between Rigid and Flex Cystoscopy, and Does it Require Local Anasthesia?","status":"COMPLETED","sponsor":"Assaf-Harofeh Medical Center","startDate":"2017-03-01","conditions":"Hematuria, Dysuria, Recurrent Uti","enrollment":120},{"nctId":"NCT03637582","phase":"NA","title":"Contribution of Urethral Sensory Feedback in Voiding Efficiency","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-11-26","conditions":"Urethral Anesthesia","enrollment":18},{"nctId":"NCT02517931","phase":"NA","title":"Sphenopalatine Ganglion Block for Postdural Puncture Headache in the Emergency Department","status":"WITHDRAWN","sponsor":"University of Arkansas","startDate":"2019-01-01","conditions":"Postdural Puncture Headache","enrollment":""},{"nctId":"NCT03390790","phase":"PHASE4","title":"Lidocaine for Pain After Urodynamic Testing","status":"COMPLETED","sponsor":"Atlantic Health System","startDate":"2018-01-25","conditions":"Voiding Disorders, Overactive Bladder, Urinary Incontinence","enrollment":134},{"nctId":"NCT02738203","phase":"PHASE3","title":"Self-Administered Lidocaine Gel for Pain Management With IUD Insertion","status":"COMPLETED","sponsor":"Stanford University","startDate":"2016-06-01","conditions":"IUD Insertion","enrollment":220},{"nctId":"NCT03881293","phase":"NA","title":"Effects of Topical Lidocaine During Urodynamic Testing In Women","status":"COMPLETED","sponsor":"Kristine Zinkgraf","startDate":"2013-12","conditions":"Urinary Stress Incontinence, Pain","enrollment":110},{"nctId":"NCT03831321","phase":"PHASE4","title":"The Effect of Preemptive Analgesia On The Comfort Of Patient and Doctor, in Cystoscopy","status":"UNKNOWN","sponsor":"Taha Uçar","startDate":"2018-12-11","conditions":"Bladder Cancer, Benign Prostate Hyperplasia, Hematuria","enrollment":144},{"nctId":"NCT03347721","phase":"PHASE4","title":"Does Lidocaine Gel Decrease Pain Perception in Women Undergoing Diagnostic Flexible Cystoscopy","status":"UNKNOWN","sponsor":"Louisiana State University Health Sciences Center in New Orleans","startDate":"2016-12-01","conditions":"Cystoscopy, Lidocaine, Pain Perception","enrollment":129},{"nctId":"NCT01411995","phase":"NA","title":"Cervical Lidocaine for Intrauterine Device Insertion Pain","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2011-08","conditions":"Pain","enrollment":200},{"nctId":"NCT02256969","phase":"PHASE4","title":"Intraductal Meibomian Gland Probing Trial","status":"COMPLETED","sponsor":"Joseph B. Ciolino, MD","startDate":"2014-10","conditions":"Meibomian Gland Dysfunction","enrollment":45},{"nctId":"NCT01534520","phase":"NA","title":"Self-administered Intravaginal 2% Lidocaine Gel Prior to Intrauterine Device Insertion in Nulliparous Women","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2012-06","conditions":"Pain","enrollment":61},{"nctId":"NCT02682134","phase":"PHASE4","title":"Sore Throat Prevention Following Intubation","status":"COMPLETED","sponsor":"University of Jordan","startDate":"2015-11","conditions":"Sore Throat","enrollment":300},{"nctId":"NCT01690767","phase":"PHASE2","title":"A Study to Assess the Ability of 2% Lidocaine Gel to Reduce the Discomfort of Urethral Catheterization","status":"COMPLETED","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2011-12","conditions":"Urinary Tract Infection","enrollment":133},{"nctId":"NCT01612156","phase":"NA","title":"Lubricant Versus Lidocaine Gel for Pain Control During Urodynamics","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2011-12","conditions":"Pelvic Floor Disorders","enrollment":90},{"nctId":"NCT00883103","phase":"PHASE4","title":"Double Blinded Randomized Trial Between Lidocaine And Plain Gel For Urethral Straight Catheterization And The Q-Tip Test","status":"COMPLETED","sponsor":"Baystate Medical Center","startDate":"2007-11","conditions":"Pain","enrollment":137},{"nctId":"NCT01192490","phase":"NA","title":"Topical Lidocaine on the Cervix and Intra-Cervical Prior to Insertion of Intrauterine Devices","status":"UNKNOWN","sponsor":"University of Tennessee","startDate":"2010-08","conditions":"Contraception","enrollment":210},{"nctId":"NCT00841386","phase":"PHASE2, PHASE3","title":"Treatment of Keratoconus Using Collagen Cross-Linking","status":"UNKNOWN","sponsor":"University at Buffalo","startDate":"2008-09","conditions":"Keratoconus","enrollment":150},{"nctId":"NCT00596375","phase":"NA","title":"Lidocaine Lubricant in Pediatric Urethral Catheterization","status":"COMPLETED","sponsor":"Children's Healthcare of Atlanta","startDate":"2006-08","conditions":"Fevers, Pain","enrollment":47}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["xylocaine jelly (2%) AstraZeneca"],"phase":"marketed","status":"active","brandName":"Lidocaine lubricant","genericName":"Lidocaine lubricant","companyName":"Simon Fraser University","companyId":"simon-fraser-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Topical anesthesia and lubrication for medical procedures, Catheterization and urological procedures, Endoscopic procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}