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Lidocaine injection flushed
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and topical use, Ventricular arrhythmias (systemic use).
At a glance
| Generic name | Lidocaine injection flushed |
|---|---|
| Also known as | Xylocaine |
| Sponsor | Wake Forest University Health Sciences |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby blocking the generation and propagation of action potentials. This reversible blockade of nerve conduction results in loss of sensation in the injected area. The term 'flushed' likely refers to a preparation or administration method rather than a distinct mechanism.
Approved indications
- Local anesthesia for infiltration, nerve block, and topical use
- Ventricular arrhythmias (systemic use)
Common side effects
- Injection site reactions (pain, erythema)
- Systemic toxicity (CNS effects: dizziness, tremor, seizures)
- Cardiovascular effects (hypotension, bradycardia)
- Allergic reactions
Key clinical trials
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy (NA)
- Ondansetron As a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial (PHASE2)
- Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation Treating Recurrent Pterygium Trial (NA)
- A Pilot Study of Intranasal Lidocaine in Acute Management of Pediatric Migraine (PHASE1)
- Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes (NA)
- General Anesthesia With or Without Local Ear Block in Middle Ear Surgeries (NA)
- Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain (PHASE4)
- Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur® After Cesarean Delivery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine injection flushed CI brief — competitive landscape report
- Lidocaine injection flushed updates RSS · CI watch RSS
- Wake Forest University Health Sciences portfolio CI