{"id":"lidocaine-injection-flushed","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema)"},{"rate":null,"effect":"Systemic toxicity (CNS effects: dizziness, tremor, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, bradycardia)"},{"rate":"rare","effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby blocking the generation and propagation of action potentials. This reversible blockade of nerve conduction results in loss of sensation in the injected area. The term 'flushed' likely refers to a preparation or administration method rather than a distinct mechanism.","oneSentence":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:03.663Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for infiltration, nerve block, and topical use"},{"name":"Ventricular arrhythmias (systemic use)"}]},"trialDetails":[{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT05378113","phase":"PHASE2","title":"Ondansetron As a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial","status":"RECRUITING","sponsor":"Emory University","startDate":"2023-05-18","conditions":"Injection Site Irritation","enrollment":120},{"nctId":"NCT05362253","phase":"NA","title":"Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation Treating Recurrent Pterygium Trial","status":"COMPLETED","sponsor":"Yifeng Yu","startDate":"2021-03-01","conditions":"Recurrent Pterygium, Micro-Conjunctival Autografting Combined With Amniotic Membrane Transplantation","enrollment":40},{"nctId":"NCT03806595","phase":"PHASE1","title":"A Pilot Study of Intranasal Lidocaine in Acute Management of Pediatric Migraine","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2019-07-03","conditions":"Migraine in Children, Posttraumatic Headache","enrollment":30},{"nctId":"NCT00992914","phase":"NA","title":"Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2009-02","conditions":"Hot Flashes, Menopause","enrollment":40},{"nctId":"NCT03569046","phase":"NA","title":"General Anesthesia With or Without Local Ear Block in Middle Ear Surgeries","status":"COMPLETED","sponsor":"Abd-Elazeem Abd-Elhameed Elbakry","startDate":"2018-07-06","conditions":"Tympanum; Perforation","enrollment":80},{"nctId":"NCT03057704","phase":"PHASE4","title":"Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2016-12-05","conditions":"Injections, Intravenous","enrollment":50},{"nctId":"NCT00804609","phase":"NA","title":"Effects of Epidural Lidocaine on the Pharmacokinetic and Pharmacodynamic Profiles of DepoDur® After Cesarean Delivery","status":"COMPLETED","sponsor":"Stanford University","startDate":"2008-09","conditions":"Epidural Analgesia, Obstetric","enrollment":30},{"nctId":"NCT03240783","phase":"PHASE2","title":"A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain","status":"UNKNOWN","sponsor":"St George Hospital, Australia","startDate":"2017-07-08","conditions":"Acute Sciatica","enrollment":60},{"nctId":"NCT01538758","phase":"NA","title":"Ultrasound Guided Needling Versus Ultrasound Guided Corticosteroid Injection Alone, a Randomized Controlled Trial.","status":"UNKNOWN","sponsor":"Medisch Spectrum Twente","startDate":"2012-07","conditions":"Calcific Tendinitis","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Xylocaine"],"phase":"marketed","status":"active","brandName":"Lidocaine injection flushed","genericName":"Lidocaine injection flushed","companyName":"Wake Forest University Health Sciences","companyId":"wake-forest-university-health-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and topical use, Ventricular arrhythmias (systemic use).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}