Last reviewed 2026-04-22 · How we verify

Lidocaine HCl 0.8% in D5W

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local and regional anesthesia, Ventricular arrhythmias (acute management).

At a glance

Mechanism of action

Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission. The 0.8% concentration in D5W (dextrose 5% in water) is formulated for intravenous infusion, typically used for systemic anesthetic or antiarrhythmic effects.

Approved indications

• Local anesthesia for infiltration, nerve block, and topical use
• Acute ventricular arrhythmias (intravenous formulation)

Common side effects

• Lightheadedness or dizziness
• Nervousness or anxiety
• Tremor
• Hypotension
• Bradycardia
• Cardiac arrhythmias (at high doses)
• Methemoglobinemia (rare)

Key clinical trials

• The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (PHASE4)

Primary sources

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