{"id":"lidocaine-hcl-0-8-in-d5w","safety":{"commonSideEffects":[{"rate":null,"effect":"Lightheadedness or dizziness"},{"rate":null,"effect":"Nervousness or anxiety"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Cardiac arrhythmias (at high doses)"},{"rate":null,"effect":"Methemoglobinemia (rare)"}]},"_chembl":{"chemblId":"CHEMBL541521","moleculeType":"Small molecule","molecularWeight":"270.80"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission. The 0.8% concentration in D5W (dextrose 5% in water) is formulated for intravenous infusion, typically used for systemic anesthetic or antiarrhythmic effects.","oneSentence":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:14.607Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for infiltration, nerve block, and topical use"},{"name":"Acute ventricular arrhythmias (intravenous formulation)"}]},"trialDetails":[{"nctId":"NCT07224711","phase":"PHASE4","title":"The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery","status":"NOT_YET_RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2026-07-01","conditions":"Pain, Post Operative Analgesia, Opioid Consumption, Postoperative","enrollment":2290}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Lidocaine HCl 0.8% in D5W","genericName":"Lidocaine HCl 0.8% in D5W","companyName":"Vanderbilt University Medical Center","companyId":"vanderbilt-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local and regional anesthesia, Ventricular arrhythmias (acute management).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}