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lidocaine and sufentanil
Lidocaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that binds to mu opioid receptors to provide analgesia and sedation.
Lidocaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that binds to mu opioid receptors to provide analgesia and sedation. Used for Local anesthesia and analgesia for medical procedures, Pain management in perioperative settings.
At a glance
| Generic name | lidocaine and sufentanil |
|---|---|
| Sponsor | RenJi Hospital |
| Drug class | Local anesthetic and opioid analgesic combination |
| Target | Voltage-gated sodium channels (lidocaine); mu opioid receptor (sufentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
This is a combination product where lidocaine acts as a local anesthetic by inhibiting sodium influx in nerve fibers, preventing pain signal transmission at the site of administration. Sufentanil, a potent synthetic opioid, activates mu opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria. Together, they provide both local and systemic pain relief.
Approved indications
- Local anesthesia and analgesia for medical procedures
- Pain management in perioperative settings
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Local site reactions
Key clinical trials
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Cardiac Index and General Anesthesia Without Opioid. (PHASE2, PHASE3)
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- LIdocaine veRsus Sufentanil Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass
- Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass
- Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
- Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery (NA)
- Effect of Lidocaine Aerosol Plus Low-dose Cisatracurium vs Conventional-dose Cisatracurium on Intubation Conditions in ERCP - A Randomized Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lidocaine and sufentanil CI brief — competitive landscape report
- lidocaine and sufentanil updates RSS · CI watch RSS
- RenJi Hospital portfolio CI