{"id":"lidocaine-and-sufentanil","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Local site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a combination product where lidocaine acts as a local anesthetic by inhibiting sodium influx in nerve fibers, preventing pain signal transmission at the site of administration. Sufentanil, a potent synthetic opioid, activates mu opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria. Together, they provide both local and systemic pain relief.","oneSentence":"Lidocaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that binds to mu opioid receptors to provide analgesia and sedation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:52:13.763Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia and analgesia for medical procedures"},{"name":"Pain management in perioperative settings"}]},"trialDetails":[{"nctId":"NCT07491991","phase":"PHASE4","title":"Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery","status":"COMPLETED","sponsor":"Qianfoshan Hospital","startDate":"2025-03-02","conditions":"Postoperative Pain, NEBULIZATION, Thyroid Surgery","enrollment":96},{"nctId":"NCT05446623","phase":"PHASE2, PHASE3","title":"Cardiac Index and General Anesthesia Without Opioid.","status":"COMPLETED","sponsor":"Centre Hospitalier de Montauban","startDate":"2021-01-01","conditions":"Hip Arthropathy, Hip Disease","enrollment":120},{"nctId":"NCT07414706","phase":"PHASE3","title":"Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2026-03","conditions":"Intravenous Lidocaine, Laparoscopic Surgery, Post Operative Recovery","enrollment":182},{"nctId":"NCT05136794","phase":"","title":"LIdocaine veRsus Sufentanil Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2021-12-01","conditions":"Opioid Free Anaesthesia, Opioid Anaesthesia","enrollment":1772},{"nctId":"NCT03816592","phase":"","title":"Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2019-01-01","conditions":"Opioid Free Anaesthesia, Opioid Anaesthesia","enrollment":110},{"nctId":"NCT07377630","phase":"PHASE4","title":"Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section","status":"NOT_YET_RECRUITING","sponsor":"Istituto Giannina Gaslini","startDate":"2026-03-01","conditions":"Pregnancy, Cesarean Section, Neuroaxial Analgesia Procedures","enrollment":100},{"nctId":"NCT07264556","phase":"NA","title":"Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-11-01","conditions":"Colorectal Cancer, Opioid-free Anesthesia, NETs","enrollment":90},{"nctId":"NCT07185074","phase":"PHASE4","title":"Effect of Lidocaine Aerosol Plus Low-dose Cisatracurium vs Conventional-dose Cisatracurium on Intubation Conditions in ERCP - A Randomized Trial","status":"RECRUITING","sponsor":"Jiangang Song","startDate":"2025-01-17","conditions":"Intubation, Intratracheal","enrollment":188},{"nctId":"NCT07084753","phase":"NA","title":"Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy","status":"NOT_YET_RECRUITING","sponsor":"IVO JURISIC","startDate":"2025-07-30","conditions":"Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy )","enrollment":36},{"nctId":"NCT06155903","phase":"NA","title":"Peripheral Nerve Blocks vs Selective Spinal Anesthesia in Patients With Femur Fracture","status":"COMPLETED","sponsor":"Federico II University","startDate":"2023-12-31","conditions":"Femur Fracture, Peripheral Nerve Block, Spinal Anesthesia","enrollment":78},{"nctId":"NCT05411159","phase":"NA","title":"Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery","status":"COMPLETED","sponsor":"Beijing Chao Yang Hospital","startDate":"2022-06-07","conditions":"Postoperative Nausea and Vomiting, Opioid Use, Thoracic Diseases","enrollment":168},{"nctId":"NCT06778460","phase":"NA","title":"Effect of Esketamine and Lidocaine on Postoperative Chronic Pain and Long-term Survival in Patients Undergoing Hepatectomy","status":"RECRUITING","sponsor":"West China Hospital","startDate":"2023-05-05","conditions":"Postoperative Chronic Pain","enrollment":304},{"nctId":"NCT06367218","phase":"NA","title":"Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS","status":"RECRUITING","sponsor":"Tongji Hospital","startDate":"2024-10-01","conditions":"Video-assisted Thoracoscopic Lung Surgery；Anesthesia","enrollment":480},{"nctId":"NCT06729515","phase":"NA","title":"Rhomboid Intercostal Block with Subserratus Plane Block in Bariatric Surgery","status":"COMPLETED","sponsor":"Xiaguang Duan","startDate":"2023-01-01","conditions":"Obesity/therapy","enrollment":114},{"nctId":"NCT06721195","phase":"","title":"Study on the Feelings of Euphoria Caused by Remimazolam During Gastroscopy and Colonoscopy and Their Related Factors","status":"RECRUITING","sponsor":"Zhangjie Yu","startDate":"2024-08-01","conditions":"Euphoria, Remimazolam Besylate, Gastrointestinal Endoscopy","enrollment":305},{"nctId":"NCT05750056","phase":"PHASE4","title":"Dose Systemic Lidocaine Improve the Quality of Recovery After Colorectal Endoscopic Submucosal Dissection","status":"COMPLETED","sponsor":"Fujian Provincial Hospital","startDate":"2023-02-24","conditions":"Postoperative Recovery","enrollment":234},{"nctId":"NCT06405776","phase":"NA","title":"Effect of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Surgery","status":"RECRUITING","sponsor":"West China Hospital","startDate":"2023-06-05","conditions":"Colorectal Cancer","enrollment":276},{"nctId":"NCT05492669","phase":"PHASE2","title":"Intravenous Lidocaine on Chronic Pain in Patients Undergoing Hepatectomy","status":"RECRUITING","sponsor":"West China Hospital","startDate":"2020-02-27","conditions":"Postoperative Chronic Pain","enrollment":260},{"nctId":"NCT05899127","phase":"PHASE4","title":"Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)","status":"UNKNOWN","sponsor":"Second Hospital of Shanxi Medical University","startDate":"2023-07-22","conditions":"Stress Reaction","enrollment":80},{"nctId":"NCT04144933","phase":"PHASE3","title":"Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Saskatchewan","startDate":"2021-05-15","conditions":"Anesthesia, General Anesthesia, Analgesics, Opioid","enrollment":60},{"nctId":"NCT05497492","phase":"NA","title":"Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine on Tussis Reflection During Upper Gastroscopy","status":"UNKNOWN","sponsor":"Beijing Friendship Hospital","startDate":"2022-11-05","conditions":"Anesthesia","enrollment":400},{"nctId":"NCT06069219","phase":"","title":"Pharmacokinetics of Sufentanil After Epidural Administration","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2019-06-01","conditions":"Epidural; Anesthesia, Epidural Analgesia, Abdominal Surgery","enrollment":18},{"nctId":"NCT05957653","phase":"PHASE4","title":"Lidocaine Combined With Sufentanil for Preventing Catheter-related Bladder Discomfort","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2023-10-07","conditions":"Prostate Cancer","enrollment":140},{"nctId":"NCT03318133","phase":"NA","title":"Comparison of CLSB With Sedation Versus General Endotracheal Anesthesia on Postoperative Outcomes in Elderly Patients Undergoing Hip Fracture Surgery","status":"UNKNOWN","sponsor":"Shanghai 6th People's Hospital","startDate":"2018-12-04","conditions":"Anesthesia Morbidity, Anesthesia; Adverse Effect","enrollment":1086},{"nctId":"NCT04295330","phase":"NA","title":"Efficacy of Intravenous Lidocaine on Postoperative Pain and Recovery in Patients Undergoing Hepatectomy","status":"COMPLETED","sponsor":"West China Hospital","startDate":"2020-02-27","conditions":"Primary Liver Cancer","enrollment":260},{"nctId":"NCT05450055","phase":"NA","title":"Intraperitoneal Lidocaine in Ovarian Cancer Surgery","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2022-07-18","conditions":"Ovarian Cancer, Post Operative Pain","enrollment":60},{"nctId":"NCT04390698","phase":"NA","title":"Opioid Free Anesthesia in Breast Cancer Surgery","status":"COMPLETED","sponsor":"Peking University People's Hospital","startDate":"2020-07-01","conditions":"Opioid Free Anesthesia","enrollment":80},{"nctId":"NCT04797312","phase":"PHASE3","title":"Comparison of an Opioid-Free Anesthesia Protocol Versus Standard Practices on Early and Late Post-operative Recovery","status":"UNKNOWN","sponsor":"University Hospital, Angers","startDate":"2021-07-12","conditions":"Anesthesia, Anesthesia; Adverse Effect, Opioid Analgesic Adverse Reaction","enrollment":140},{"nctId":"NCT04948385","phase":"PHASE4","title":"Driving Performance After Deep Sedation for Outpatient Endoscopy","status":"COMPLETED","sponsor":"University of Liege","startDate":"2019-02-06","conditions":"Driving Impaired","enrollment":60},{"nctId":"NCT02505880","phase":"NA","title":"Hypnosis Versus General Anesthesia in Pediatric Surgery: Clinical and Medico-economic Interests","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2015-06","conditions":"Minimally Invasive Surgery","enrollment":60},{"nctId":"NCT04854577","phase":"NA","title":"Postoperative Opioid-Sparing Effect of a Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia.","status":"UNKNOWN","sponsor":"Algemeen Stedelijk Ziekenhuis","startDate":"2021-05","conditions":"Opioid Free Anaesthesia, Opioid Anaesthesia","enrollment":64},{"nctId":"NCT04788732","phase":"","title":"Heart Rate Variability to Quantify General Anesthesia Depth","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"2021-01-04","conditions":"Anesthesia Awareness","enrollment":200},{"nctId":"NCT03202134","phase":"","title":"Impact of Opioid Free Anesthesia on Outcome After DIEPflap Surgery","status":"COMPLETED","sponsor":"AZ Sint-Jan AV","startDate":"2014-01","conditions":"Major and Minor Surgical Complications","enrollment":204},{"nctId":"NCT04538235","phase":"","title":"Analgesic Non Inferiority of the Thoracic Bi-block in Comparison With Thoracic Epidural for VATS.","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2019-10-20","conditions":"Erector Spinae Muscle Plane Block, Serratus Anterior Muscle Plane Block, Video-Assisted Thoracic Surgery","enrollment":90},{"nctId":"NCT04507165","phase":"NA","title":"Opioid-free Anesthesia in VATS Lung Resection","status":"UNKNOWN","sponsor":"Peking University People's Hospital","startDate":"2020-08","conditions":"Opioid Free Anesthesia","enrollment":100},{"nctId":"NCT03086213","phase":"NA","title":"Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients","status":"COMPLETED","sponsor":"Shenzhen Third People's Hospital","startDate":"2017-03-01","conditions":"Peripheral Solitary Pulmonary Nodule or Tuberculoma","enrollment":48},{"nctId":"NCT02752477","phase":"PHASE3","title":"Efficacy of Opioid-free Anesthesia in Reducing Postoperative Pain in Chronic Pain Patients Undergoing Spinal Surgery","status":"UNKNOWN","sponsor":"Ben Lim","startDate":"2016-08-02","conditions":"Chronic Pain, Anesthesia","enrollment":30},{"nctId":"NCT03660306","phase":"","title":"Impact of OFA During LPV on Postoperative Oxygen Saturation","status":"COMPLETED","sponsor":"AZ Sint-Jan AV","startDate":"2018-08-01","conditions":"Decreased Lung Compliance, Oxygen Requirement","enrollment":64},{"nctId":"NCT03738137","phase":"NA","title":"Narcotrend Versus Bispectral Index Monitoring During Sufentanil-Midazolam Anesthesia for Bronchoscopy","status":"COMPLETED","sponsor":"Guangzhou Institute of Respiratory Disease","startDate":"2018-08-01","conditions":"Bronchoscopy","enrollment":80},{"nctId":"NCT03890094","phase":"","title":"Safety and Efficacy of Sufentanil Combined With Midazolam in Bronchoscopy Under Conscious Sedation: Retrospective Study","status":"COMPLETED","sponsor":"Guangzhou Institute of Respiratory Disease","startDate":"2018-01-01","conditions":"Bronchoscopy, Sedation","enrollment":11158},{"nctId":"NCT03792776","phase":"NA","title":"Effect of Lidocaine 1% and 2% in the Tube Cuff on Postoperative Sore Throat and Cough","status":"UNKNOWN","sponsor":"Ogarite Habib","startDate":"2019-01","conditions":"Postoperative Sore Throat, Postoperative Cough","enrollment":150},{"nctId":"NCT03600272","phase":"NA","title":"Comparison of Combined Spinal-epidural Analgesia Versus Epidural Analgesia for Pain Management During Labor","status":"UNKNOWN","sponsor":"Deng Dongrui","startDate":"2018-07-20","conditions":"Labor Long, Labor Pain, Labor Fetal Anoxia","enrollment":200},{"nctId":"NCT03381495","phase":"NA","title":"The Association Between Epidural Labor Analgesia and Pregnancy Outcomes","status":"UNKNOWN","sponsor":"Deng Dongrui","startDate":"2018-05-16","conditions":"Labor Pain, Pregnancy Outcomes, Psychological Disorder","enrollment":200},{"nctId":"NCT01283087","phase":"","title":"Spinal Anesthesia Using Lidocaine and Sufentanil and (Transient Neurological Symptoms) TNS","status":"COMPLETED","sponsor":"Vestre Viken Ringerike Sykehus","startDate":"2011-01","conditions":"Transient Neurologic Symptoms","enrollment":168},{"nctId":"NCT03124680","phase":"NA","title":"Opioid Free Anesthesia and Continuous Post-operative Pulse Oximetry Monitoring in the Obese Patient","status":"COMPLETED","sponsor":"Université Libre de Bruxelles","startDate":"2017-04-20","conditions":"Anesthesia","enrollment":30},{"nctId":"NCT01691937","phase":"PHASE2","title":"Continuous Paravertebral Block on Postoperative Pain After Hepatectomy","status":"COMPLETED","sponsor":"Huazhong University of Science and Technology","startDate":"2012-09","conditions":"Right Lobe Hepatectomy","enrollment":48},{"nctId":"NCT01617811","phase":"NA","title":"Effect of Epidural Anesthesia and Analgesia on Patients' Outcomes After Liver Resection","status":"COMPLETED","sponsor":"Sir Run Run Shaw Hospital","startDate":"2007-08","conditions":"Hepatectomy","enrollment":26},{"nctId":"NCT01572116","phase":"PHASE2","title":"Effect of Sufentanil on the Rate of Anesthesia","status":"COMPLETED","sponsor":"Islamic Azad University, Sanandaj","startDate":"2010-01","conditions":"Irreversible Pulpitis","enrollment":60},{"nctId":"NCT01124383","phase":"NA","title":"The Impact of Anesthesia on the Absorption of Glycine in Operative Hysteroscopy: a Randomized Controlled Trial","status":"COMPLETED","sponsor":"CHU de Quebec-Universite Laval","startDate":"2008-08","conditions":"The Absorption of Glycine in Operative Hysteroscopy","enrollment":95}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":197,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"lidocaine and sufentanil","genericName":"lidocaine and sufentanil","companyName":"RenJi Hospital","companyId":"renji-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that binds to mu opioid receptors to provide analgesia and sedation. Used for Local anesthesia and analgesia for medical procedures, Pain management in perioperative settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}