Last reviewed 2026-05-15 · How we verify

lidocaine+adjunct tramadol

Lidocaine is a local anesthetic that blocks sodium channels to prevent nerve impulses, while tramadol is a weak opioid agonist that also inhibits serotonin and norepinephrine reuptake.

Lidocaine is a local anesthetic that blocks sodium channels to prevent nerve impulses, while tramadol is a weak opioid agonist that also inhibits serotonin and norepinephrine reuptake. Used for Postoperative pain, acute pain, chronic pain.

At a glance

Mechanism of action

Lidocaine's mechanism of action is primarily through the blockade of voltage-gated sodium channels, preventing the initiation and transmission of nerve impulses. Tramadol, on the other hand, acts as a weak agonist at the mu-opioid receptor, as well as an inhibitor of the serotonin and norepinephrine transporters, leading to increased levels of these neurotransmitters in the synaptic cleft.

Approved indications

• Postoperative pain, acute pain, chronic pain

Common side effects

• Dizziness
• Nausea
• Vomiting
• Headache
• Drowsiness

Key clinical trials

• Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery (PHASE3)

Primary sources

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