{"id":"lidocaine-adjunct-tramadol","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Drowsiness"}]},"_chembl":{"chemblId":"CHEMBL1237065","moleculeType":"Small molecule","molecularWeight":"299.84"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Lidocaine's mechanism of action is primarily through the blockade of voltage-gated sodium channels, preventing the initiation and transmission of nerve impulses. Tramadol, on the other hand, acts as a weak agonist at the mu-opioid receptor, as well as an inhibitor of the serotonin and norepinephrine transporters, leading to increased levels of these neurotransmitters in the synaptic cleft.","oneSentence":"Lidocaine is a local anesthetic that blocks sodium channels to prevent nerve impulses, while tramadol is a weak opioid agonist that also inhibits serotonin and norepinephrine reuptake.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:18:53.654Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain, acute pain, chronic pain"}]},"trialDetails":[{"nctId":"NCT02658721","phase":"PHASE3","title":"Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery","status":"COMPLETED","sponsor":"Bagcilar Training and Research Hospital","startDate":"2013-01","conditions":"Anesthesia","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["tramadol"],"phase":"phase_3","status":"active","brandName":"lidocaine+adjunct tramadol","genericName":"lidocaine+adjunct tramadol","companyName":"Bagcilar Training and Research Hospital","companyId":"bagcilar-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine is a local anesthetic that blocks sodium channels to prevent nerve impulses, while tramadol is a weak opioid agonist that also inhibits serotonin and norepinephrine reuptake. Used for Postoperative pain, acute pain, chronic pain.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}