Last reviewed 2026-04-23 · How we verify

levofloxacin; amoxicillin/clavulanate

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, while amoxicillin/clavulanate inhibits bacterial cell wall synthesis.

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, while amoxicillin/clavulanate inhibits bacterial cell wall synthesis. Used for Community-acquired pneumonia, Skin and skin structure infections.

At a glance

Mechanism of action

Levofloxacin is a fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV, essential for DNA replication and transcription. Amoxicillin/clavulanate is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by targeting penicillin-binding proteins.

Approved indications

• Community-acquired pneumonia
• Skin and skin structure infections

Common side effects

• Nausea
• Diarrhea
• Vomiting
• Abdominal pain
• Headache

Key clinical trials

• Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP (PHASE4)
• A Platform Trial for Gram Negative Bloodstream Infections (NA)
• Early Antibiotics After Aspiration in ICU Patients (PHASE4)
• Comparing Oral Versus Parenteral Antimicrobial Therapy (PHASE4)
• Effect of Topical Sinonasal Antibiotics (PHASE2)
• An Exploratory Study of TMC207 in Japanese Participants With Pulmonary Multi-Drug Resistant Tuberculosis (MDR-TB) (PHASE2)
• BALANCE+ Vanguard Phase (NA)
• Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis (PHASE4)

Primary sources

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