Last reviewed · How we verify
Levobupivacaine wound infiltration
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia and analgesia for wound infiltration during surgical procedures.
At a glance
| Generic name | Levobupivacaine wound infiltration |
|---|---|
| Sponsor | University of Genova |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and action potential propagation. When infiltrated into wound tissue, it provides local anesthesia and analgesia by blocking sensory and motor nerve conduction in the infiltrated area.
Approved indications
- Local anesthesia and analgesia for wound infiltration during surgical procedures
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Local tissue irritation or inflammation
- Allergic reactions
Key clinical trials
- Advantage of Tramadol in Local Analgesia Post-Sternotomy (PHASE4)
- TAP Block Versus Local Anesthesia Wound Infiltration for Postoperative Pain Relief After Appendicectomy in Children (NA)
- Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery. (PHASE4)
- Local Wound Anesthesia in Spine Surgery (NA)
- Long-term Outcomes of Breast Cancer Patients After Wound Infiltration Analgesia (PHASE4)
- The Impact of Fast-track Perioperative Program After Liver Resection in Hong Kong Chinese Patients (NA)
- Local Wound Infiltration With 0.5% Levobupivacaine for Postoperative Pain After Laparoscopic Colorectal Surgery. (NA)
- Local Wound Infiltration for Tracheal Reconstruction (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Levobupivacaine wound infiltration CI brief — competitive landscape report
- Levobupivacaine wound infiltration updates RSS · CI watch RSS
- University of Genova portfolio CI