{"id":"levobupivacaine-wound-infiltration","safety":{"commonSideEffects":[{"rate":null,"effect":"Systemic toxicity (CNS effects: tremor, seizures)"},{"rate":null,"effect":"Cardiovascular effects (hypotension, arrhythmias)"},{"rate":null,"effect":"Local tissue irritation or inflammation"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is the S-enantiomer of bupivacaine, a long-acting amide local anesthetic. It works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and action potential propagation. When infiltrated into wound tissue, it provides local anesthesia and analgesia by blocking sensory and motor nerve conduction in the infiltrated area.","oneSentence":"Levobupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:33:58.661Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia and analgesia for wound infiltration during surgical procedures"}]},"trialDetails":[{"nctId":"NCT02851394","phase":"PHASE4","title":"Advantage of Tramadol in Local Analgesia Post-Sternotomy","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Dijon","startDate":"2015-10","conditions":"Heart Surgery Via Sternotomy, Post-operative Analgesia","enrollment":160},{"nctId":"NCT04969133","phase":"NA","title":"TAP Block Versus Local Anesthesia Wound Infiltration for Postoperative Pain Relief After Appendicectomy in Children","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Besancon","startDate":"2021-07-30","conditions":"Appendicitis Acute, Pediatrics, Analgesia","enrollment":110},{"nctId":"NCT03809442","phase":"PHASE4","title":"Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2019-06-25","conditions":"Postoperative Analgesia","enrollment":116},{"nctId":"NCT05693454","phase":"NA","title":"Local Wound Anesthesia in Spine Surgery","status":"COMPLETED","sponsor":"Balgrist University Hospital","startDate":"2021-11-01","conditions":"Surgical Wound, Orthopedic Disorder of Spine","enrollment":150},{"nctId":"NCT05829707","phase":"PHASE4","title":"Long-term Outcomes of Breast Cancer Patients After Wound Infiltration Analgesia","status":"COMPLETED","sponsor":"Osijek University Hospital","startDate":"2009-01-05","conditions":"Postoperative Analgesia, Hand Strength, Health Related Quality of Life","enrollment":120},{"nctId":"NCT03223818","phase":"NA","title":"The Impact of Fast-track Perioperative Program After Liver Resection in Hong Kong Chinese Patients","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2018-07-01","conditions":"Liver Cancer","enrollment":94},{"nctId":"NCT03433014","phase":"NA","title":"Local Wound Infiltration With 0.5% Levobupivacaine for Postoperative Pain After Laparoscopic Colorectal Surgery.","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2018-03-31","conditions":"Laparoscopic Colorectal Surgery, Colorectal Cancer","enrollment":30},{"nctId":"NCT02949661","phase":"NA","title":"Local Wound Infiltration for Tracheal Reconstruction","status":"WITHDRAWN","sponsor":"Mansoura University","startDate":"2016-09","conditions":"Upper Tracheal Resection, Tracheal Reconstruction Surgery","enrollment":""},{"nctId":"NCT04000308","phase":"NA","title":"QLB vs. Wound Infiltration in Cesarean Section","status":"COMPLETED","sponsor":"University Medical Centre Ljubljana","startDate":"2019-08-28","conditions":"Analgesia, Cesarean Section","enrollment":116},{"nctId":"NCT04294537","phase":"NA","title":"TAP Block or Wound Infiltration for Laparoscopic Pediatric Appendectomy: a Pilot Study","status":"UNKNOWN","sponsor":"Ospedale di Circolo - 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Used for Local anesthesia and analgesia for wound infiltration during surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}