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L. reuteri Prodentis® lozenges
L. reuteri Prodentis® is a probiotic lozenge containing Lactobacillus reuteri that colonizes the oral cavity and modulates the local oral microbiome to reduce pathogenic bacteria and promote gum health.
L. reuteri Prodentis® is a probiotic lozenge containing Lactobacillus reuteri that colonizes the oral cavity and modulates the local oral microbiome to reduce pathogenic bacteria and promote gum health. Used for Gingivitis and periodontal disease prevention and management, Oral microbiome modulation for gum health.
At a glance
| Generic name | L. reuteri Prodentis® lozenges |
|---|---|
| Sponsor | University of Zagreb |
| Drug class | Probiotic |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Oral Health |
| Phase | FDA-approved |
Mechanism of action
The live L. reuteri bacteria in the lozenge establish themselves in the oral cavity where they produce antimicrobial compounds and compete with pathogenic oral bacteria. This shifts the oral microbiota composition toward a healthier balance, reducing inflammation and supporting periodontal tissue health. The mechanism relies on competitive exclusion and production of bacteriocins rather than a specific molecular target.
Approved indications
- Gingivitis and periodontal disease prevention and management
- Oral microbiome modulation for gum health
Common side effects
- Mild oral irritation
- Taste alteration
Key clinical trials
- The Effect of Probiotic Lozenges on White Spot Lesion Development in Orthodontic Patients (NA)
- Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients (NA)
- Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment (NA)
- Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis (PHASE4)
- Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- L. reuteri Prodentis® lozenges CI brief — competitive landscape report
- L. reuteri Prodentis® lozenges updates RSS · CI watch RSS
- University of Zagreb portfolio CI