{"id":"l-reuteri-prodentis-lozenges","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild oral irritation"},{"rate":null,"effect":"Taste alteration"}]},"_chembl":{"chemblId":"CHEMBL58832","moleculeType":"Small molecule","molecularWeight":"132.12"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The live L. reuteri bacteria in the lozenge establish themselves in the oral cavity where they produce antimicrobial compounds and compete with pathogenic oral bacteria. This shifts the oral microbiota composition toward a healthier balance, reducing inflammation and supporting periodontal tissue health. The mechanism relies on competitive exclusion and production of bacteriocins rather than a specific molecular target.","oneSentence":"L. reuteri Prodentis® is a probiotic lozenge containing Lactobacillus reuteri that colonizes the oral cavity and modulates the local oral microbiome to reduce pathogenic bacteria and promote gum health.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:18.184Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gingivitis and periodontal disease prevention and management"},{"name":"Oral microbiome modulation for gum health"}]},"trialDetails":[{"nctId":"NCT05738369","phase":"NA","title":"The Effect of Probiotic Lozenges on White Spot Lesion Development in Orthodontic Patients","status":"UNKNOWN","sponsor":"Jordan University of Science and Technology","startDate":"2022-02-14","conditions":"White Spot Lesion","enrollment":75},{"nctId":"NCT04606186","phase":"NA","title":"Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment in Adult Patients","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg","startDate":"2020-10-19","conditions":"Gingivitis, Periodontal Inflammation, Orthodontic Appliance Complication","enrollment":34},{"nctId":"NCT04598633","phase":"NA","title":"Influence of Probiotics on Clinical Parameters, the Oral Microbiome and the Immune System During an Orthodontic Treatment","status":"UNKNOWN","sponsor":"University of Erlangen-Nürnberg","startDate":"2020-11-24","conditions":"Gingivitis, Orthodontic Appliance Complication","enrollment":34},{"nctId":"NCT02789436","phase":"PHASE4","title":"Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis","status":"UNKNOWN","sponsor":"University of Zagreb","startDate":"2016-06","conditions":"Halitosis","enrollment":30},{"nctId":"NCT02692625","phase":"PHASE4","title":"Consumption Effect of Probiotic Products on Salivary Cariogenic Bacterial Counts in Preschool Children.","status":"UNKNOWN","sponsor":"King Abdulaziz University","startDate":"2015-01","conditions":"Dental Caries","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"L. reuteri Prodentis® lozenges","genericName":"L. reuteri Prodentis® lozenges","companyName":"University of Zagreb","companyId":"university-of-zagreb","modality":"Small molecule","firstApprovalDate":"","aiSummary":"L. reuteri Prodentis® is a probiotic lozenge containing Lactobacillus reuteri that colonizes the oral cavity and modulates the local oral microbiome to reduce pathogenic bacteria and promote gum health. Used for Gingivitis and periodontal disease prevention and management, Oral microbiome modulation for gum health.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}