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L-BUPIVACAINE ; MORPHINE
This combination uses L-bupivacaine (a local anesthetic) and morphine (an opioid analgesic) to provide regional anesthesia and postoperative pain relief through blockade of nerve conduction and opioid receptor activation.
This combination uses L-bupivacaine (a local anesthetic) and morphine (an opioid analgesic) to provide regional anesthesia and postoperative pain relief through blockade of nerve conduction and opioid receptor activation. Used for Postoperative pain management, Regional anesthesia with systemic analgesia.
At a glance
| Generic name | L-BUPIVACAINE ; MORPHINE |
|---|---|
| Also known as | PERIDURAL L-BUPIVACAINE, PCA MORPHINE |
| Sponsor | Corporacion Parc Tauli |
| Drug class | Local anesthetic + opioid analgesic combination |
| Target | Voltage-gated sodium channels (L-bupivacaine); mu-opioid receptor (morphine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | Phase 3 |
Mechanism of action
L-bupivacaine is the active S-enantiomer of bupivacaine that blocks sodium channels in nerve fibers, preventing pain signal transmission when administered locally or regionally. Morphine acts systemically as a mu-opioid receptor agonist to provide additional analgesia. The combination is designed to provide both local anesthetic effect and systemic opioid analgesia for perioperative pain management.
Approved indications
- Postoperative pain management
- Regional anesthesia with systemic analgesia
Common side effects
- Nausea and vomiting
- Dizziness or lightheadedness
- Hypotension
- Respiratory depression
- Pruritus
- Local site reactions
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- Efficacy of Erector Spinae Plane Block in Major Video-assisted Thoracic Surgery Compared to Intrathecal Morphine and Intercostal Nerve Block.
- Observational Retrospective Study on Spinal Analgesia in Laparoscopic and Laparotomic Hysterectomy
- Erector Spinae Plane Block in Lumbar Spinal Fusion (NA)
- Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery (PHASE4)
- Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery (PHASE4)
- Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy (PHASE1)
- Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- L-BUPIVACAINE ; MORPHINE CI brief — competitive landscape report
- L-BUPIVACAINE ; MORPHINE updates RSS · CI watch RSS
- Corporacion Parc Tauli portfolio CI