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The combination is designed to provide both local anesthetic effect and systemic opioid analgesia for perioperative pain management.","oneSentence":"This combination uses L-bupivacaine (a local anesthetic) and morphine (an opioid analgesic) to provide regional anesthesia and postoperative pain relief through blockade of nerve conduction and opioid receptor activation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:18:01.445Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management"},{"name":"Regional anesthesia with systemic analgesia"}]},"trialDetails":[{"nctId":"NCT07489001","phase":"","title":"Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","status":"RECRUITING","sponsor":"Marmara University","startDate":"2025-12-09","conditions":"Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis","enrollment":75},{"nctId":"NCT07441161","phase":"","title":"Efficacy of Erector Spinae Plane Block in Major Video-assisted Thoracic Surgery Compared to Intrathecal Morphine and Intercostal Nerve Block.","status":"COMPLETED","sponsor":"Hospital Donostia","startDate":"2023-01-09","conditions":"Video Assisted Thoracic Surgery (VATS), Erector Spinae Plane Block, Regional Anaesthesia","enrollment":113},{"nctId":"NCT05654363","phase":"","title":"Observational Retrospective Study on Spinal Analgesia in Laparoscopic and Laparotomic Hysterectomy","status":"COMPLETED","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2023-03-13","conditions":"Pain, Postoperative, Hysterectomy, Morphine","enrollment":670},{"nctId":"NCT04904575","phase":"NA","title":"Erector Spinae Plane Block in Lumbar Spinal Fusion","status":"RECRUITING","sponsor":"Clinique Saint Jean, France","startDate":"2022-01-03","conditions":"Lumbar Spinal Fusion","enrollment":130},{"nctId":"NCT06935708","phase":"PHASE4","title":"Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery","status":"RECRUITING","sponsor":"Meri Mirceta","startDate":"2025-04-08","conditions":"Colorectal Carcinoma, Analgesia, Postoperative, Laparotomy","enrollment":98},{"nctId":"NCT06881563","phase":"PHASE4","title":"Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery","status":"NOT_YET_RECRUITING","sponsor":"Meri Mirceta","startDate":"2025-03","conditions":"Postoperative Pain, Analgesia, Colorectal Cancer","enrollment":98},{"nctId":"NCT06595329","phase":"PHASE1","title":"Comparison Between Epidural Analgesia and Intrathecal Opioid Analgesia for Pain Management in Open Nephrectomy","status":"RECRUITING","sponsor":"University Hospital of Split","startDate":"2025-01-15","conditions":"Pain, Renal Cancer, Surgical Procedure, Unspecified","enrollment":40},{"nctId":"NCT06864312","phase":"PHASE4","title":"Rebound Pain Following Regional Anaesthesia for Ankle Fracture Surgery","status":"COMPLETED","sponsor":"University College Cork","startDate":"2023-10-16","conditions":"Ankle Fracture (bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Ankle Fracture - Lateral Malleolus, Ankle Fracture - Medial Malleolus","enrollment":120},{"nctId":"NCT04172220","phase":"NA","title":"Does Type of Anesthesia Influence Inflammation Change After Breast Surgery?","status":"COMPLETED","sponsor":"Centro di Riferimento Oncologico - Aviano","startDate":"2019-10-31","conditions":"Breast Cancer Female","enrollment":68},{"nctId":"NCT06488014","phase":"NA","title":"Comparison of the Effect of Preoperative and Postoperative Erector Spina Plan Block and Paravertebral Block on Postoperative Pain in Video Assisted Thoracic Surgery (VATS)","status":"NOT_YET_RECRUITING","sponsor":"Ankara University","startDate":"2024-09-01","conditions":"Anesthesia, Nerve Block, Pain, Postoperative","enrollment":78},{"nctId":"NCT02689024","phase":"PHASE4","title":"Delirium in Elderly Patients With Trauma of the Hip","status":"TERMINATED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2016-05","conditions":"Hip Fractures, Anesthesia","enrollment":239},{"nctId":"NCT05831761","phase":"NA","title":"Effectivness of Tramadol or Topic Lidocaine on Postoperative Analgesia in Laparoscopic Colorectal Resection.","status":"COMPLETED","sponsor":"University Medical Centre Ljubljana","startDate":"2009-09-01","conditions":"Postoperative Pain","enrollment":83},{"nctId":"NCT05308420","phase":"PHASE4","title":"PENG Block vs Intrathecal Morphine in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Kresimir Oremus, MD","startDate":"2022-04-03","conditions":"Total Hip Arthroplasty, Postoperative Pain","enrollment":60},{"nctId":"NCT03825198","phase":"PHASE3","title":"Lumbar Erector Spinae Plane Block for Back Surgery","status":"UNKNOWN","sponsor":"Dr M. 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and opioid receptor activation. 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