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Ketoprofen topical
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain at the site of topical application. Used for Topical treatment of localized pain and inflammation associated with musculoskeletal conditions, Osteoarthritis pain relief.
At a glance
| Generic name | Ketoprofen topical |
|---|---|
| Sponsor | Handok Inc. |
| Drug class | NSAID (nonsteroidal anti-inflammatory drug) |
| Target | COX-1, COX-2 |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Rheumatology |
| Phase | Phase 3 |
Mechanism of action
Ketoprofen blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. When applied topically, it penetrates the skin to reach underlying tissues and joints, providing localized anti-inflammatory and analgesic effects with reduced systemic exposure compared to oral formulations.
Approved indications
- Topical treatment of localized pain and inflammation associated with musculoskeletal conditions
- Osteoarthritis pain relief
Common side effects
- Skin irritation or erythema at application site
- Pruritus
- Contact dermatitis
Key clinical trials
- Effect of Phonophoresis on Trigger Points (NA)
- Multiprofen-CC to Reduce Pain in Hand Arthritis (PHASE3)
- Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty (PHASE3)
- Lymphedema Treatment Registry
- A Study to Assess Efficacy and Safety of the Ketoprofen vs Diclofenac (PHASE3)
- Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis (PHASE3)
- Ketoprofen Topical Patch, 20% in the Treatment of Pain Associated With Osteoarthritis Flare of the Knee (PHASE3)
- Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Ankle Sprain or Strain (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketoprofen topical CI brief — competitive landscape report
- Ketoprofen topical updates RSS · CI watch RSS
- Handok Inc. portfolio CI