Last reviewed 2026-04-23 · How we verify

Ivermectin Injectable Product

Ivermectin is a macrocyclic lactone that binds to glutamate-gated chloride channels in parasites and some pathogens, causing paralysis and death.

Ivermectin is a macrocyclic lactone that binds to glutamate-gated chloride channels in parasites and some pathogens, causing paralysis and death. Used for Parasitic infections (onchocerciasis, strongyloidiasis, scabies), Investigational use in COVID-19 and other infectious diseases (phase 3 context suggests expanded indication study).

At a glance

Mechanism of action

Ivermectin selectively activates chloride channels in invertebrate nervous and muscular systems, leading to hyperpolarization, paralysis, and death of susceptible organisms. The injectable formulation allows systemic delivery for treatment of parasitic and certain infectious diseases. It has also been investigated for potential antiviral and immunomodulatory properties in various conditions.

Approved indications

• Parasitic infections (onchocerciasis, strongyloidiasis, scabies)
• Investigational use in COVID-19 and other infectious diseases (phase 3 context suggests expanded indication study)

Common side effects

• Mazzotti reaction (fever, pruritus, rash)
• Headache
• Myalgia
• Lymphadenopathy
• Gastrointestinal disturbances

Key clinical trials

• Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) (PHASE3)
• Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (PHASE3)
• Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19
• Efficacy of Subcutaneous Ivermectin With or Without Zinc in COVID-19 Patients (PHASE1, PHASE2)
• Ivermectin, Aspirin, Dexamethasone and Enoxaparin as Treatment of Covid 19

Primary sources

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