{"id":"ivermectin-injectable-product","safety":{"commonSideEffects":[{"rate":null,"effect":"Mazzotti reaction (fever, pruritus, rash)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Lymphadenopathy"},{"rate":null,"effect":"Gastrointestinal disturbances"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ivermectin selectively activates chloride channels in invertebrate nervous and muscular systems, leading to hyperpolarization, paralysis, and death of susceptible organisms. The injectable formulation allows systemic delivery for treatment of parasitic and certain infectious diseases. It has also been investigated for potential antiviral and immunomodulatory properties in various conditions.","oneSentence":"Ivermectin is a macrocyclic lactone that binds to glutamate-gated chloride channels in parasites and some pathogens, causing paralysis and death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:32.135Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Parasitic infections (onchocerciasis, strongyloidiasis, scabies)"},{"name":"Investigational use in COVID-19 and other infectious diseases (phase 3 context suggests expanded indication study)"}]},"trialDetails":[{"nctId":"NCT04966702","phase":"PHASE3","title":"Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA)","status":"COMPLETED","sponsor":"Barcelona Institute for Global Health","startDate":"2022-03-17","conditions":"Malaria","enrollment":48145},{"nctId":"NCT02735707","phase":"PHASE3","title":"Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia","status":"RECRUITING","sponsor":"UMC Utrecht","startDate":"2016-04-11","conditions":"Community-acquired Pneumonia, Influenza, COVID-19","enrollment":20000},{"nctId":"NCT05045937","phase":"","title":"Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19","status":"UNKNOWN","sponsor":"Patrick Robinson","startDate":"2022-05-01","conditions":"Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection","enrollment":1000},{"nctId":"NCT04472585","phase":"PHASE1, PHASE2","title":"Efficacy of Subcutaneous Ivermectin With or Without Zinc in COVID-19 Patients","status":"UNKNOWN","sponsor":"Sohaib Ashraf","startDate":"2020-11-14","conditions":"Coronavirus Infection, COVID, Sars-CoV2","enrollment":180},{"nctId":"NCT04425863","phase":"","title":"Ivermectin, Aspirin, Dexamethasone and Enoxaparin as Treatment of Covid 19","status":"COMPLETED","sponsor":"Eurnekian Public Hospital","startDate":"2020-05-01","conditions":"Severe Acute Respiratory Syndrome, Ventilation Pneumonitis","enrollment":167}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Veterinary Ivermectin 1%"],"phase":"phase_3","status":"active","brandName":"Ivermectin Injectable Product","genericName":"Ivermectin Injectable Product","companyName":"Barcelona Institute for Global Health","companyId":"barcelona-institute-for-global-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ivermectin is a macrocyclic lactone that binds to glutamate-gated chloride channels in parasites and some pathogens, causing paralysis and death. Used for Parasitic infections (onchocerciasis, strongyloidiasis, scabies), Investigational use in COVID-19 and other infectious diseases (phase 3 context suggests expanded indication study).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}