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Ivermectin 0.1% Metronidazole 1%
Ivermectin 0.1% Metronidazole 1% is a Antiparasitic/Antimicrobial combination Small molecule drug developed by Universidad Nacional de Colombia. It is currently in Phase 3 development for Parasitic and anaerobic bacterial skin infections (investigational). Also known as: 22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b.
This combination product uses ivermectin to paralyze parasites and metronidazole to disrupt microbial DNA, targeting parasitic and anaerobic bacterial infections.
This combination product uses ivermectin to paralyze parasites and metronidazole to disrupt microbial DNA, targeting parasitic and anaerobic bacterial infections. Used for Parasitic and anaerobic bacterial skin infections (investigational).
At a glance
| Generic name | Ivermectin 0.1% Metronidazole 1% |
|---|---|
| Also known as | 22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b |
| Sponsor | Universidad Nacional de Colombia |
| Drug class | Antiparasitic/Antimicrobial combination |
| Target | Glutamate-gated chloride channels (ivermectin); DNA/anaerobic metabolism (metronidazole) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Dermatology |
| Phase | Phase 3 |
Mechanism of action
Ivermectin binds to glutamate-gated chloride channels in parasites, causing paralysis and death. Metronidazole is a nitroimidazole that generates reactive oxygen species and damages DNA in anaerobic organisms. Together, they provide broad-spectrum activity against parasites and anaerobic bacteria, likely for topical or systemic treatment of mixed infections.
Approved indications
- Parasitic and anaerobic bacterial skin infections (investigational)
Common side effects
- Skin irritation or burning
- Pruritus
- Erythema
- Metallic taste (if systemic absorption)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ivermectin 0.1% Metronidazole 1% CI brief — competitive landscape report
- Ivermectin 0.1% Metronidazole 1% updates RSS · CI watch RSS
- Universidad Nacional de Colombia portfolio CI
Frequently asked questions about Ivermectin 0.1% Metronidazole 1%
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Related
- Drug class: All Antiparasitic/Antimicrobial combination drugs
- Target: All drugs targeting Glutamate-gated chloride channels (ivermectin); DNA/anaerobic metabolism (metronidazole)
- Manufacturer: Universidad Nacional de Colombia — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Dermatology
- Indication: Drugs for Parasitic and anaerobic bacterial skin infections (investigational)
- Also known as: 22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b
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