Last reviewed · How we verify
IV PCA Fentanyl+nefopam+Ramosetron
This IV patient-controlled analgesia (PCA) combination provides opioid analgesia via fentanyl, reduces postoperative nausea and vomiting via ramosetron (5-HT3 antagonist), and enhances analgesia while reducing opioid requirements via nefopam (non-opioid analgesic).
This IV patient-controlled analgesia (PCA) combination provides opioid analgesia via fentanyl, reduces postoperative nausea and vomiting via ramosetron (5-HT3 antagonist), and enhances analgesia while reducing opioid requirements via nefopam (non-opioid analgesic). Used for Postoperative pain management via intravenous patient-controlled analgesia.
At a glance
| Generic name | IV PCA Fentanyl+nefopam+Ramosetron |
|---|---|
| Also known as | intravenous patient-controlled analgesia |
| Sponsor | Keimyung University Dongsan Medical Center |
| Drug class | Opioid analgesic combination with antiemetic and adjuvant analgesic |
| Target | Mu-opioid receptor (fentanyl); 5-HT3 receptor (ramosetron); monoamine transporters and NMDA receptor (nefopam) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Fentanyl is a potent mu-opioid receptor agonist that provides the primary analgesic effect. Ramosetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone neurons to prevent nausea and vomiting. Nefopam is a non-opioid analgesic that works through monoamine reuptake inhibition and NMDA receptor antagonism, reducing total opioid consumption and improving pain control.
Approved indications
- Postoperative pain management via intravenous patient-controlled analgesia
Common side effects
- Nausea and vomiting
- Dizziness
- Sedation
- Respiratory depression
- Hypotension
- Pruritus
Key clinical trials
- The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery (NA)
- Prospective Randomized Trial Comparing the Effectiveness of Continuous Paravertebral Infusion of Local Anesthetics Versus Intravenous Patient-controlled Analgesia on Acute and Chronic Neuropathic Pain After VATS Lobectomy (PHASE2)
- Differences in Incidence of Common Side Effects Between Young Adults and Elderly Patients While Using IV-PCA
- The Comparison Between Epidural and Intravenous Patient-controlled Analgesia for Laparoscopic Gastrectomy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: