{"id":"iv-pca-fentanyl-nefopam-ramosetron","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl is a potent mu-opioid receptor agonist that provides the primary analgesic effect. Ramosetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone neurons to prevent nausea and vomiting. Nefopam is a non-opioid analgesic that works through monoamine reuptake inhibition and NMDA receptor antagonism, reducing total opioid consumption and improving pain control.","oneSentence":"This IV patient-controlled analgesia (PCA) combination provides opioid analgesia via fentanyl, reduces postoperative nausea and vomiting via ramosetron (5-HT3 antagonist), and enhances analgesia while reducing opioid requirements via nefopam (non-opioid analgesic).","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:48:59.015Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management via intravenous patient-controlled analgesia"}]},"trialDetails":[{"nctId":"NCT03462836","phase":"NA","title":"The Effects of Optimizing Post-operative Pain Management With Multi Modal Analgesia on Immune Suppression and Oncologic Outcome in Patients Undergoing Laparoscopic Colorectal Surgery","status":"WITHDRAWN","sponsor":"Yonsei University","startDate":"2019-04","conditions":"Laparoscopic Colorectal Resection Due to Cancer","enrollment":""},{"nctId":"NCT01703351","phase":"PHASE2","title":"Prospective Randomized Trial Comparing the Effectiveness of Continuous Paravertebral Infusion of Local Anesthetics Versus Intravenous Patient-controlled Analgesia on Acute and Chronic Neuropathic Pain After VATS Lobectomy","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2012-10-04","conditions":"Lung Neoplasms, Postoperative Pain","enrollment":79},{"nctId":"NCT02448862","phase":"","title":"Differences in Incidence of Common Side Effects Between Young Adults and Elderly Patients While Using IV-PCA","status":"COMPLETED","sponsor":"Severance Hospital","startDate":"2015-05","conditions":"Pain, Postoperative, Postoperative Nausea and Vomiting","enrollment":10575},{"nctId":"NCT02444897","phase":"PHASE3","title":"The Comparison Between Epidural and Intravenous Patient-controlled Analgesia for Laparoscopic Gastrectomy","status":"COMPLETED","sponsor":"Keimyung University Dongsan Medical Center","startDate":"2013-09","conditions":"Gastric Cancer","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["intravenous patient-controlled analgesia"],"phase":"phase_3","status":"active","brandName":"IV PCA Fentanyl+nefopam+Ramosetron","genericName":"IV PCA Fentanyl+nefopam+Ramosetron","companyName":"Keimyung University Dongsan Medical Center","companyId":"keimyung-university-dongsan-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This IV patient-controlled analgesia (PCA) combination provides opioid analgesia via fentanyl, reduces postoperative nausea and vomiting via ramosetron (5-HT3 antagonist), and enhances analgesia while reducing opioid requirements via nefopam (non-opioid analgesic). Used for Postoperative pain management via intravenous patient-controlled analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}