Last reviewed · How we verify
Isopropyl alcohol & Chlorhexidine Gluconate Antiseptic
Isopropyl alcohol and chlorhexidine gluconate work synergistically as a broad-spectrum antiseptic by disrupting bacterial cell membranes and denaturing proteins to rapidly kill microorganisms on skin.
Isopropyl alcohol and chlorhexidine gluconate work synergistically as a broad-spectrum antiseptic by disrupting bacterial cell membranes and denaturing proteins to rapidly kill microorganisms on skin. Used for Skin antisepsis and disinfection prior to medical procedures, Wound cleansing and antisepsis, Preoperative skin preparation.
At a glance
| Generic name | Isopropyl alcohol & Chlorhexidine Gluconate Antiseptic |
|---|---|
| Also known as | Project X 26ml, Project X 10.5ml, Project X 5.1ml |
| Sponsor | Professional Disposables International, Inc. |
| Drug class | Topical antiseptic combination |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention / Dermatology |
| Phase | Phase 3 |
Mechanism of action
Isopropyl alcohol acts as a rapid antimicrobial agent by denaturing proteins and disrupting lipid membranes, while chlorhexidine gluconate provides sustained antimicrobial activity through membrane disruption and nucleic acid interference. Together, they provide both immediate and residual antimicrobial efficacy against a wide range of gram-positive and gram-negative bacteria, fungi, and some viruses, making them effective for skin antisepsis and disinfection.
Approved indications
- Skin antisepsis and disinfection prior to medical procedures
- Wound cleansing and antisepsis
- Preoperative skin preparation
Common side effects
- Skin irritation
- Contact dermatitis
- Drying of skin
Key clinical trials
- CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee (NA)
- Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections (PHASE4)
- Skin Preparation for Elective Foot and Ankle Surgery (PHASE4)
- SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty (PHASE4)
- Perioperative Patient Skin Antiseptic Preparation Evaluation (PHASE3)
- Comparison of Two Preoperative Antiseptic Solutions Alcohol Based in Abdominal Elective Surgeries (PHASE4)
- ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions (PHASE3)
- Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: