{"id":"isopropyl-alcohol-chlorhexidine-gluconate-antiseptic","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Drying of skin"}]},"_chembl":{"chemblId":"CHEMBL4297088","moleculeType":"Small molecule","molecularWeight":"897.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Isopropyl alcohol acts as a rapid antimicrobial agent by denaturing proteins and disrupting lipid membranes, while chlorhexidine gluconate provides sustained antimicrobial activity through membrane disruption and nucleic acid interference. Together, they provide both immediate and residual antimicrobial efficacy against a wide range of gram-positive and gram-negative bacteria, fungi, and some viruses, making them effective for skin antisepsis and disinfection.","oneSentence":"Isopropyl alcohol and chlorhexidine gluconate work synergistically as a broad-spectrum antiseptic by disrupting bacterial cell membranes and denaturing proteins to rapidly kill microorganisms on skin.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:21.137Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin antisepsis and disinfection prior to medical procedures"},{"name":"Wound cleansing and antisepsis"},{"name":"Preoperative skin preparation"}]},"trialDetails":[{"nctId":"NCT05828810","phase":"NA","title":"CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2023-07-25","conditions":"Revision Total Hip Arthroplasty (RTHA), Revision Total Knee Arthroplasty","enrollment":400},{"nctId":"NCT05920122","phase":"PHASE4","title":"Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections","status":"COMPLETED","sponsor":"Hyagriv Simhan","startDate":"2023-10-09","conditions":"Surgical Site Infection, Cesarean Section; Infection","enrollment":1398},{"nctId":"NCT05401292","phase":"PHASE4","title":"Skin Preparation for Elective Foot and Ankle Surgery","status":"RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2022-02-15","conditions":"Microbial Colonization, Foot and Ankle Disorders","enrollment":100},{"nctId":"NCT05919888","phase":"PHASE4","title":"SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty","status":"COMPLETED","sponsor":"St. Louis University","startDate":"2023-06-26","conditions":"Surgery, Surgical Site Infection, Cutibacterium Acnes","enrollment":60},{"nctId":"NCT04756804","phase":"PHASE3","title":"Perioperative Patient Skin Antiseptic Preparation Evaluation","status":"COMPLETED","sponsor":"Zurex Pharma, Inc.","startDate":"2021-06-21","conditions":"Surgical Site Infection","enrollment":51},{"nctId":"NCT03859908","phase":"PHASE4","title":"Comparison of Two Preoperative Antiseptic Solutions Alcohol Based in Abdominal Elective Surgeries","status":"TERMINATED","sponsor":"Universidad de El Salvador","startDate":"2019-04-05","conditions":"Surgical Site Infection","enrollment":18},{"nctId":"NCT03838575","phase":"PHASE3","title":"ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions","status":"UNKNOWN","sponsor":"University of Birmingham","startDate":"2019-03-01","conditions":"Surgical Site Infection, Surgical Wound Infection, Surgery--Complications","enrollment":6610},{"nctId":"NCT03861780","phase":"PHASE3","title":"Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation","status":"COMPLETED","sponsor":"Professional Disposables International, Inc.","startDate":"2019-04-02","conditions":"Bacteria Microflora Reduction","enrollment":152},{"nctId":"NCT04218110","phase":"PHASE3","title":"Preoperative Skin Preparation Study to Evaluate the Antimicrobial Capabilities of Four Test Substances","status":"COMPLETED","sponsor":"Professional Disposables International, Inc.","startDate":"2020-02-11","conditions":"Surgical Site Infection","enrollment":329},{"nctId":"NCT03817580","phase":"PHASE3","title":"Comparative Study of Antimicrobial Effectiveness","status":"COMPLETED","sponsor":"Professional Disposables International, Inc.","startDate":"2019-02-18","conditions":"Bacterial Microflora Reduction","enrollment":170},{"nctId":"NCT03229824","phase":"NA","title":"Use of Clorhexidine Dressings to Reduce Surgical Site Infections in Breast Cancer Surgery. A Controlled Clinical Trial","status":"COMPLETED","sponsor":"National Institute of Cancerología","startDate":"2016-10-03","conditions":"Breast Cancer","enrollment":116},{"nctId":"NCT01216761","phase":"NA","title":"A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2008-05","conditions":"Bacteremia","enrollment":3879},{"nctId":"NCT01361997","phase":"PHASE3","title":"Isopropyl Alcohol Against Chlorhexidine - Isopropyl Alcohol as Antiseptics to Prevent Hemoculture's Contamination","status":"COMPLETED","sponsor":"Universidad de Guanajuato","startDate":"2011-06","conditions":"Infectious Diseases","enrollment":1102},{"nctId":"NCT02391714","phase":"NA","title":"Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion","status":"COMPLETED","sponsor":"University of New Mexico","startDate":"2013-10","conditions":"Contraception","enrollment":80},{"nctId":"NCT01762904","phase":"PHASE3","title":"Residual Effect of Chlorhexidine-alcohol Compared to Triclosan-alcohol","status":"COMPLETED","sponsor":"Universidad de Guanajuato","startDate":"2013-01","conditions":"Infectious Diseases","enrollment":135},{"nctId":"NCT01321125","phase":"PHASE3","title":"Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics","status":"COMPLETED","sponsor":"Universidad de Guanajuato","startDate":"2011-04","conditions":"Infectious Diseases","enrollment":30},{"nctId":"NCT01270776","phase":"NA","title":"Efficacy Study Comparing 2% Chlorhexidine in 70% Isopropyl Alcohol Versus 2% Aqueous Chlorhexidine","status":"UNKNOWN","sponsor":"Mount Sinai Hospital, Canada","startDate":"2011-01","conditions":"Anti-infecting Agents, Local","enrollment":462},{"nctId":"NCT00516360","phase":"PHASE4","title":"Study of Chlorhexidine as the Hub Antiseptic to Prevent Catheter Related Infections in Newborn Infants","status":"UNKNOWN","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2007-07","conditions":"Catheterization","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":51,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Project X 26ml","Project X 10.5ml","Project X 5.1ml"],"phase":"phase_3","status":"active","brandName":"Isopropyl alcohol & Chlorhexidine Gluconate Antiseptic","genericName":"Isopropyl alcohol & Chlorhexidine Gluconate Antiseptic","companyName":"Professional Disposables International, Inc.","companyId":"professional-disposables-international-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isopropyl alcohol and chlorhexidine gluconate work synergistically as a broad-spectrum antiseptic by disrupting bacterial cell membranes and denaturing proteins to rapidly kill microorganisms on skin. Used for Skin antisepsis and disinfection prior to medical procedures, Wound cleansing and antisepsis, Preoperative skin preparation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}