Last reviewed · How we verify
isobaric mepivacaine
Isobaric mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.
Isobaric mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Local and regional anesthesia for surgical and dental procedures, Spinal anesthesia.
At a glance
| Generic name | isobaric mepivacaine |
|---|---|
| Sponsor | Thomas Jefferson University |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Mepivacaine is an amide-class local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby preventing depolarization and conduction of action potentials. The isobaric formulation is specifically adjusted to have the same specific gravity as cerebrospinal fluid, making it suitable for spinal anesthesia with predictable spread characteristics.
Approved indications
- Local and regional anesthesia for surgical and dental procedures
- Spinal anesthesia
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Neurological toxicity (at high doses)
- Allergic reactions
Key clinical trials
- Mepivacaine Vs. Bupivacaine Spinal for TKA (NA)
- Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty (PHASE2, PHASE3)
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |