{"id":"isobaric-mepivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Headache (post-dural puncture)"},{"rate":null,"effect":"Neurological toxicity (at high doses)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mepivacaine is an amide-class local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby preventing depolarization and conduction of action potentials. The isobaric formulation is specifically adjusted to have the same specific gravity as cerebrospinal fluid, making it suitable for spinal anesthesia with predictable spread characteristics.","oneSentence":"Isobaric mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:26.115Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical and dental procedures"},{"name":"Spinal anesthesia"}]},"trialDetails":[{"nctId":"NCT05765682","phase":"NA","title":"Mepivacaine Vs. Bupivacaine Spinal for TKA","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2023-03-13","conditions":"Total Knee Replacement","enrollment":160},{"nctId":"NCT03838874","phase":"PHASE2, PHASE3","title":"Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2019-02-25","conditions":"Knee Osteoarthritis, Hip Osteoarthritis","enrollment":154},{"nctId":"NCT03948386","phase":"PHASE4","title":"3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2019-05-13","conditions":"Osteoarthritis, Hip","enrollment":159}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"isobaric mepivacaine","genericName":"isobaric mepivacaine","companyName":"Thomas Jefferson University","companyId":"thomas-jefferson-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Isobaric mepivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Local and regional anesthesia for surgical and dental procedures, Spinal anesthesia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}