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ISDN ointment
ISDN (isosorbide dinitrate) is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow.
ISDN (isosorbide dinitrate) is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow. Used for Angina pectoris (prophylaxis and acute relief), Heart failure (adjunctive therapy).
At a glance
| Generic name | ISDN ointment |
|---|---|
| Sponsor | Onze Lieve Vrouwe Gasthuis |
| Drug class | Nitrate vasodilator |
| Target | Guanylate cyclase (via nitric oxide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Isosorbide dinitrate is metabolized to release nitric oxide, which activates guanylate cyclase and increases cGMP levels in vascular smooth muscle cells, leading to vasodilation. This reduces preload and afterload on the heart, improving coronary blood flow and reducing myocardial oxygen demand. As a topical ointment formulation, it provides sustained local and systemic nitrate effects for angina management.
Approved indications
- Angina pectoris (prophylaxis and acute relief)
- Heart failure (adjunctive therapy)
Common side effects
- Headache
- Dizziness
- Hypotension
- Tachycardia
- Flushing
Key clinical trials
- Assessment of the Effect of Coconut and Sunflower Seed Oil Derived Isosorbide Diseters and Colloidial Oatmeal (NA)
- Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study (PHASE3)
- Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ISDN ointment CI brief — competitive landscape report
- ISDN ointment updates RSS · CI watch RSS
- Onze Lieve Vrouwe Gasthuis portfolio CI