{"id":"isdn-ointment","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-15","effect":"Hypotension"},{"rate":"5-10","effect":"Tachycardia"},{"rate":"5-10","effect":"Flushing"}]},"_chembl":{"chemblId":"CHEMBL2108523","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Isosorbide dinitrate is metabolized to release nitric oxide, which activates guanylate cyclase and increases cGMP levels in vascular smooth muscle cells, leading to vasodilation. This reduces preload and afterload on the heart, improving coronary blood flow and reducing myocardial oxygen demand. As a topical ointment formulation, it provides sustained local and systemic nitrate effects for angina management.","oneSentence":"ISDN (isosorbide dinitrate) is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:50:15.776Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Angina pectoris (prophylaxis and acute relief)"},{"name":"Heart failure (adjunctive therapy)"}]},"trialDetails":[{"nctId":"NCT05688735","phase":"NA","title":"Assessment of the Effect of Coconut and Sunflower Seed Oil Derived Isosorbide Diseters and Colloidial Oatmeal","status":"UNKNOWN","sponsor":"Integrative Skin Science and Research","startDate":"2023-04-20","conditions":"Atopic Dermatitis","enrollment":40},{"nctId":"NCT01387672","phase":"PHASE3","title":"Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study","status":"COMPLETED","sponsor":"University of Toronto","startDate":"2011-09","conditions":"Osteoporosis","enrollment":265},{"nctId":"NCT00827736","phase":"PHASE4","title":"Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure","status":"COMPLETED","sponsor":"Onze Lieve Vrouwe Gasthuis","startDate":"2002-06","conditions":"Anal Fissure","enrollment":73}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"ISDN ointment","genericName":"ISDN ointment","companyName":"Onze Lieve Vrouwe Gasthuis","companyId":"onze-lieve-vrouwe-gasthuis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ISDN (isosorbide dinitrate) is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow. Used for Angina pectoris (prophylaxis and acute relief), Heart failure (adjunctive therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}