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Iron oligosaccharide
Iron oligosaccharide delivers iron in a carbohydrate-stabilized form that is absorbed through the gastrointestinal tract to replenish iron stores and treat iron deficiency.
Iron oligosaccharide delivers iron in a carbohydrate-stabilized form that is absorbed through the gastrointestinal tract to replenish iron stores and treat iron deficiency. Used for Iron deficiency anemia, Iron supplementation in patients with chronic kidney disease.
At a glance
| Generic name | Iron oligosaccharide |
|---|---|
| Also known as | MonoFer |
| Sponsor | Pharmacosmos A/S |
| Drug class | Iron supplement / Iron replacement therapy |
| Target | Iron (Fe2+/Fe3+) absorption pathway |
| Modality | Small molecule |
| Therapeutic area | Hematology |
| Phase | Phase 3 |
Mechanism of action
Iron oligosaccharide is an oral iron formulation where iron is complexed with oligosaccharides, which stabilize the iron and facilitate its absorption in the GI tract. This approach aims to improve bioavailability and reduce gastrointestinal side effects compared to traditional iron salts. The iron is then utilized by the body for hemoglobin synthesis and other iron-dependent processes.
Approved indications
- Iron deficiency anemia
- Iron supplementation in patients with chronic kidney disease
Common side effects
- Gastrointestinal disturbance (nausea, constipation, abdominal discomfort)
- Dark stools
- Headache
Key clinical trials
- Exercise and Galactooligosaccharide Supplementation on Inflammation and Iron Absorption (FexerGOS) (NA)
- Potential of Prebiotic Galacto-oligosaccharides in Improving Efficacy and Safety of Oral Iron Supplementation in HIV-infected Children (NA)
- Prebiotic GOS and Lactoferrin With Iron Supplements (NA)
- Iron Sucrose in Patients With Iron Deficiency and POTS (PHASE2)
- Iron Absorption From an Iron-fortified Follow-up Formula With Added Synbiotic or Human Milk Oligosaccharides (NA)
- The Effect of Human Milk Oligosaccharides and Galacto-oligosaccharides on Iron Absorption in Kenyan Infants (NA)
- The Effect of Different Prebiotics on Iron Absorption From High Dose Iron Supplements (NA)
- Determination of Iron Absorption Mechanism From Ferrous Fumarate With GOS (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |