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IPACK block
IPACK block is a regional anesthesia technique that combines infiltration of the interspace between the popliteal artery and capsule of the knee joint with a popliteal sciatic nerve block to provide perioperative analgesia for knee surgery.
IPACK block is a regional anesthesia technique that combines infiltration of the interspace between the popliteal artery and capsule of the knee joint with a popliteal sciatic nerve block to provide perioperative analgesia for knee surgery. Used for Perioperative analgesia for knee surgery (arthroscopy, arthroplasty, meniscectomy).
At a glance
| Generic name | IPACK block |
|---|---|
| Sponsor | NYU Langone Health |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
IPACK (Interspace Between the Popliteal Artery and the Capsule of the posterior knee) block targets the genicular nerves and other sensory branches supplying the posterior knee joint capsule by injecting local anesthetic into the anatomical space between the popliteal artery and the joint capsule. When combined with a popliteal sciatic nerve block, it provides comprehensive multimodal regional anesthesia for knee procedures, reducing opioid requirements and postoperative pain.
Approved indications
- Perioperative analgesia for knee surgery (arthroscopy, arthroplasty, meniscectomy)
Common side effects
- Local anesthetic toxicity
- Vascular puncture
- Nerve injury
- Hematoma
Key clinical trials
- Efficacy of IPACK Block Combined With Intra-articular Steroid Injection in Advanced Knee Osteoarthritis: A Retrospective Cohort Study
- Postoperative Analgesic Benefit of iPACK Block in the Anterior Cruciate Ligament Reconstruction Surgery (NA)
- SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty (NA)
- Peripheral Nerve Blocks and Postoperative Pain and Mobilization After Total Knee Arthroplasty
- Comparison of the Postoperative Analgesic Efficacy of Infiltration Between the Popliteal Artery and the Capsule of the Knee (iPACK) Block and the Biceps Femoris Short Head Plane (BiFeS) Block in Total Knee Arthroplasty (NA)
- Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following HTO/DFO/TTO (PHASE4)
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty (PHASE4)
- Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IPACK block CI brief — competitive landscape report
- IPACK block updates RSS · CI watch RSS
- NYU Langone Health portfolio CI