Last reviewed · How we verify
ionic iron
Ionic iron replaces depleted iron stores to restore hemoglobin synthesis and oxygen-carrying capacity in the blood.
Ionic iron replaces depleted iron stores to restore hemoglobin synthesis and oxygen-carrying capacity in the blood. Used for Iron deficiency anemia, Iron supplementation in pregnancy, Iron deficiency due to chronic blood loss.
At a glance
| Generic name | ionic iron |
|---|---|
| Also known as | Ferrous Sulphate |
| Sponsor | Milton S. Hershey Medical Center |
| Drug class | Iron supplement |
| Modality | Small molecule |
| Therapeutic area | Hematology |
| Phase | FDA-approved |
Mechanism of action
Ionic iron (ferrous or ferric salts) is absorbed in the gastrointestinal tract and incorporated into hemoglobin and myoglobin, as well as iron-dependent enzymes. It corrects iron deficiency anemia by replenishing total body iron stores and enabling normal erythropoiesis. This is a replacement therapy for iron deficiency states.
Approved indications
- Iron deficiency anemia
- Iron supplementation in pregnancy
- Iron deficiency due to chronic blood loss
Common side effects
- Gastrointestinal upset (nausea, constipation, abdominal discomfort)
- Dark stools
- Abdominal pain
- Diarrhea
Key clinical trials
- Alternate-day Versus Daily Oral Iron Therapy in Children With Iron Deficiency Anaemia (PHASE4)
- A Pilot Study Comparing Tolerance of Oral Heme Iron Polypeptide With Oral Ionic Iron (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |