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intravesical instillation with HA-CS
Intravesical instillation of hyaluronic acid and chondroitin sulfate creates a protective coating on the bladder urothelium to reduce irritation and inflammation.
Intravesical instillation of hyaluronic acid and chondroitin sulfate creates a protective coating on the bladder urothelium to reduce irritation and inflammation. Used for Interstitial cystitis / bladder pain syndrome, Recurrent urinary tract infections with bladder irritation.
At a glance
| Generic name | intravesical instillation with HA-CS |
|---|---|
| Sponsor | University Hospital, Basel, Switzerland |
| Drug class | Bladder protectant / Glycosaminoglycan replacement |
| Modality | Small molecule |
| Therapeutic area | Urology |
| Phase | FDA-approved |
Mechanism of action
HA-CS (hyaluronic acid-chondroitin sulfate) is a topical bladder coating agent that adheres to the damaged urothelial surface, forming a glycosaminoglycan layer that protects against irritants and reduces inflammatory responses. This mechanism helps restore the bladder's natural protective barrier function, particularly in conditions characterized by urothelial damage and chronic inflammation.
Approved indications
- Interstitial cystitis / bladder pain syndrome
- Recurrent urinary tract infections with bladder irritation
Common side effects
- Dysuria
- Urinary frequency
- Hematuria
- Local irritation
Key clinical trials
- Early vs Delayed Intravesical Blad-Care During BCG Therapy (NA)
- Alternative Prophylaxis in Female Recurrent Urinary Tract Infections (PHASE4)
- Multicentre International STudy for the Prevention With Ialuril® of Radio-induced Cystitis (MISTIC) (PHASE2)
- Retrospective Analysis of Ialuril vs. Standard of Care in Recurrent Urinary Tract Infections
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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