{"id":"intravesical-instillation-with-ha-cs","safety":{"commonSideEffects":[{"rate":null,"effect":"Dysuria"},{"rate":null,"effect":"Urinary frequency"},{"rate":null,"effect":"Hematuria"},{"rate":null,"effect":"Local irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"HA-CS (hyaluronic acid-chondroitin sulfate) is a topical bladder coating agent that adheres to the damaged urothelial surface, forming a glycosaminoglycan layer that protects against irritants and reduces inflammatory responses. This mechanism helps restore the bladder's natural protective barrier function, particularly in conditions characterized by urothelial damage and chronic inflammation.","oneSentence":"Intravesical instillation of hyaluronic acid and chondroitin sulfate creates a protective coating on the bladder urothelium to reduce irritation and inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:01.758Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Interstitial cystitis / bladder pain syndrome"},{"name":"Recurrent urinary tract infections with bladder irritation"}]},"trialDetails":[{"nctId":"NCT07495072","phase":"NA","title":"Early vs Delayed Intravesical Blad-Care During BCG Therapy","status":"RECRUITING","sponsor":"BLAD-HYA Group","startDate":"2025-11-03","conditions":"Urinary Bladder Neoplasms, BCG-Induced Cystitis","enrollment":56},{"nctId":"NCT04095572","phase":"PHASE4","title":"Alternative Prophylaxis in Female Recurrent Urinary Tract Infections","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2020-10-27","conditions":"Urinary Tract Infections, Urinary Tract Infection (UTI)","enrollment":50},{"nctId":"NCT03493997","phase":"PHASE2","title":"Multicentre International STudy for the Prevention With Ialuril® of Radio-induced Cystitis (MISTIC)","status":"COMPLETED","sponsor":"Study Group for Urogenital Diseases, Italy","startDate":"2017-04-04","conditions":"Prostate Cancer","enrollment":100},{"nctId":"NCT02016118","phase":"","title":"Retrospective Analysis of Ialuril vs. Standard of Care in Recurrent Urinary Tract Infections","status":"UNKNOWN","sponsor":"Study Group for Urogenital Diseases, Italy","startDate":"2014-01","conditions":"Recurrent Urinary Tract Infections","enrollment":500}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":20,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"intravesical instillation with HA-CS","genericName":"intravesical instillation with HA-CS","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravesical instillation of hyaluronic acid and chondroitin sulfate creates a protective coating on the bladder urothelium to reduce irritation and inflammation. Used for Interstitial cystitis / bladder pain syndrome, Recurrent urinary tract infections with bladder irritation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}