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Intravenous Lidocaine infusion + Standard Anesthesia
Intravenous Lidocaine infusion + Standard Anesthesia is a Local anesthetic (sodium channel blocker) Small molecule drug developed by Instituto Mexicano del Seguro Social. It is currently FDA-approved for Adjunctive analgesia during general anesthesia and surgery, Postoperative pain reduction. Also known as: Xylocaine®, Lignocaine.
Intravenous lidocaine blocks sodium channels in nerve fibers to provide local anesthesia and analgesia, used as an adjunct to standard general anesthesia.
Intravenous lidocaine blocks sodium channels in nerve fibers to provide local anesthesia and analgesia, used as an adjunct to standard general anesthesia. Used for Adjunctive analgesia during general anesthesia and surgery, Postoperative pain reduction.
At a glance
| Generic name | Intravenous Lidocaine infusion + Standard Anesthesia |
|---|---|
| Also known as | Xylocaine®, Lignocaine |
| Sponsor | Instituto Mexicano del Seguro Social |
| Drug class | Local anesthetic (sodium channel blocker) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Perioperative Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that inhibits sodium influx into nerve cells, preventing depolarization and conduction of action potentials. When administered intravenously during anesthesia, it enhances analgesia, reduces anesthetic requirements, and may decrease postoperative pain and opioid consumption. This combination approach leverages lidocaine's analgesic properties alongside conventional anesthetic agents.
Approved indications
- Adjunctive analgesia during general anesthesia and surgery
- Postoperative pain reduction
Common side effects
- Hypotension
- Bradycardia
- Dizziness
- Tinnitus
- Perioral numbness
- Seizures (at high doses)
Key clinical trials
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery (PHASE3)
- LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy (NA)
- A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis (PHASE1, PHASE2)
- Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery. (PHASE4)
- Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2 (NA)
- Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes (NA)
- Dex vs SLNB in Spontaneous Breathing Via THRIVE for Laryngeal Surgery (NA)
- Minimal Flow Anesthesia and Infection Risk (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intravenous Lidocaine infusion + Standard Anesthesia CI brief — competitive landscape report
- Intravenous Lidocaine infusion + Standard Anesthesia updates RSS · CI watch RSS
- Instituto Mexicano del Seguro Social portfolio CI
Frequently asked questions about Intravenous Lidocaine infusion + Standard Anesthesia
What is Intravenous Lidocaine infusion + Standard Anesthesia?
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Related
- Drug class: All Local anesthetic (sodium channel blocker) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Instituto Mexicano del Seguro Social — full pipeline
- Therapeutic area: All drugs in Anesthesia and Perioperative Pain Management
- Indication: Drugs for Adjunctive analgesia during general anesthesia and surgery
- Indication: Drugs for Postoperative pain reduction
- Also known as: Xylocaine®, Lignocaine
- Compare: Intravenous Lidocaine infusion + Standard Anesthesia vs similar drugs
- Pricing: Intravenous Lidocaine infusion + Standard Anesthesia cost, discount & access