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Intravenous iron supplementation
Intravenous iron supplementation replenishes depleted iron stores by delivering iron directly into the bloodstream for absorption and utilization in hemoglobin and myoglobin synthesis.
Intravenous iron supplementation replenishes depleted iron stores by delivering iron directly into the bloodstream for absorption and utilization in hemoglobin and myoglobin synthesis. Used for Iron deficiency anemia, Anemia of chronic kidney disease, Iron deficiency in patients intolerant or unresponsive to oral iron therapy.
At a glance
| Generic name | Intravenous iron supplementation |
|---|---|
| Sponsor | University of Pecs |
| Drug class | Iron supplement |
| Target | Iron (Fe2+/Fe3+) for hemoglobin and myoglobin synthesis |
| Modality | Small molecule |
| Therapeutic area | Hematology |
| Phase | FDA-approved |
Mechanism of action
Iron is an essential mineral required for oxygen transport via hemoglobin in red blood cells and for energy production in mitochondria. IV iron bypasses gastrointestinal absorption limitations, allowing rapid repletion of iron stores in patients with iron deficiency anemia, chronic kidney disease, or those intolerant of oral iron. The iron is incorporated into transferrin for transport and subsequently utilized by erythroid progenitor cells and other iron-dependent tissues.
Approved indications
- Iron deficiency anemia
- Anemia of chronic kidney disease
- Iron deficiency in patients intolerant or unresponsive to oral iron therapy
Common side effects
- Injection site reactions (pain, discoloration)
- Hypersensitivity reactions
- Headache
- Nausea
- Dizziness
- Abdominal pain
Key clinical trials
- Iron and Immune Response to Vaccine (IRONMUM) (NA)
- Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome (PHASE4)
- Oral Versus Intravenous Iron for Anemia Diagnosed After 34 Weeks of Gestation (NA)
- Patient Blood Management in Cardiac Surgery (NA)
- EFFICACY OF IV VERSUS ORAL IRON IN THE TREATMENT OF IRON DEFICIENCY ANEMIA DURING PREGNANCY (PHASE1)
- IntraVenous Iron in Kids With Iron Deficiency and Scoliosis Study (PHASE2, PHASE3)
- Postoperative Intravenous Ferric Derisomaltose for Prevention of Long-term Anemia After Cardiac Surgery (PHASE4)
- Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum Depression (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intravenous iron supplementation CI brief — competitive landscape report
- Intravenous iron supplementation updates RSS · CI watch RSS
- University of Pecs portfolio CI