{"id":"intravenous-iron-supplementation","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, discoloration)"},{"rate":null,"effect":"Hypersensitivity reactions"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Abdominal pain"}]},"_chembl":{"chemblId":"CHEMBL1200823","moleculeType":"Small molecule","molecularWeight":"398.14"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Iron is an essential mineral required for oxygen transport via hemoglobin in red blood cells and for energy production in mitochondria. IV iron bypasses gastrointestinal absorption limitations, allowing rapid repletion of iron stores in patients with iron deficiency anemia, chronic kidney disease, or those intolerant of oral iron. The iron is incorporated into transferrin for transport and subsequently utilized by erythroid progenitor cells and other iron-dependent tissues.","oneSentence":"Intravenous iron supplementation replenishes depleted iron stores by delivering iron directly into the bloodstream for absorption and utilization in hemoglobin and myoglobin synthesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:49:50.037Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Iron deficiency anemia"},{"name":"Anemia of chronic kidney disease"},{"name":"Iron deficiency in patients intolerant or unresponsive to oral iron therapy"}]},"trialDetails":[{"nctId":"NCT05385042","phase":"NA","title":"Iron and Immune Response to Vaccine (IRONMUM)","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2022-06-18","conditions":"Pregnancy Related","enrollment":171},{"nctId":"NCT07476859","phase":"PHASE4","title":"Effect of Intravenous Iron on Quality of Life in Older 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Postpartum","enrollment":30},{"nctId":"NCT00952302","phase":"NA","title":"Study of the Effects of Iron Levels on the Lungs at High Altitude","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2008-10","conditions":"Pulmonary Hypertension, Mountain Sickness","enrollment":33},{"nctId":"NCT00210002","phase":"PHASE2","title":"Evaluation of Iron Supplementation During Darbepoetin Alfa Treatment in Prophylaxis of Severe Anaemia Chemo-Induced","status":"TERMINATED","sponsor":"Institut Claudius Regaud","startDate":"2003-11","conditions":"Neoplasms, Anemia","enrollment":55},{"nctId":"NCT00125996","phase":"PHASE1, PHASE2","title":"Effect of Intravenous Ferrous Sucrose on Exercise Capacity in Chronic Heart Failure","status":"UNKNOWN","sponsor":"National Heart and Lung Institute","startDate":"2004-07","conditions":"Chronic Heart Failure, Heart Diseases, Anemia, Iron-Deficiency","enrollment":42}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":366,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Intravenous iron supplementation","genericName":"Intravenous iron supplementation","companyName":"University of Pecs","companyId":"university-of-pecs","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Intravenous iron supplementation replenishes depleted iron stores by delivering iron directly into the bloodstream for absorption and utilization in hemoglobin and myoglobin synthesis. Used for Iron deficiency anemia, Anemia of chronic kidney disease, Iron deficiency in patients intolerant or unresponsive to oral iron therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}